Wednesday , June 29 2022

Multiple brain regions moderate and connect the mood and pain of depression



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Depression is associated with less activity in parts of the brain thought to regulate mood, which previous research suggests might explain why depressed people demonstrate less ability to govern their ruminant thought process.

In a newspaper published online before printing, researchers at the University of California, San Diego School of Medicine are expanding and deepening that understanding, identifying certain regions of the brain that are driving, t influence and moderate mood depression and relationship to physical pain.

Write in the magazine Pain, a team led by senior author Fadel Zeidan, Ph.D., assistant professor of anesthesia at UC San Diego School of Medicine, found with colleagues in North Carolina and Ohio, the functional brain regions and areas that monitor sensory input. negative pain and mood, high and low levels.

"We were very surprised about the broad roles of these regions," Zeidan said. "Brain regions involved in pain relief were also associated with lower pain and depression. The brain parts involved in pain regulation where it is also associated with depression. n surprising after seeing the results Why should certain aspects of the brain not perform multiple roles?

Zeidan and colleagues studied 76 healthy, depressive and painless individuals who had a standardized assessment of mood and negative depression for the first time, and then exposed to unpleasant thermal (heat) stimulation. magnetic resonance scan.

The data revealed that the introductory cortex – a region of the brain that manages higher-level executive functions such as cognition, memory and behavior – is also a perception of moderate pain, along with areas of sensory discrimination, such as the secondary somatosensory cortex and insulin behind.

It was found that participants with higher levels of depression mood showed a higher sensitivity to experimental pain, with more activation in all parts of the brain in question.

"These findings illuminate the complex relationship between low mood and pain," Zeidan said. "We also hope that we can use these findings to refine our better development of behavioral and non-opioid therapies that target painful nature of chronic pain and clinical depression, resulting in better treatments for & # 39. both. "

It's thoughtful people; feel less pain; MRI visualization identifies brain activity

Magazine information:

Provided by
University of California – San Diego

Multiple brain regions moderate and connect mood and low pain (2019, May 21)
retrieved 21 May 2019

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