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Mini-placentas could provide a model for early pregnancy


Studying small plaques could help to understand the real things
Studying small plaques could help to understand the real things
Image: Shutterstock

The plaque is absolutely essential for supporting the baby as it grows inside the mother. When it does not work properly, it can lead to serious problems. Many pregnancies fail the fact that the implant is not correctly incorporated into the womb (gutter) and neglected to form a playful connection with the mother.

Due to the complexities of studying the early stages of our development, very little is known about what is happening and what can go from space.

Researchers at Cambridge University said they had succeeded in growing placenta outside the uterus that continued to grow for over a year and performed most of the organ's main functions. These developments of placenta models or organisms – provided a window to what changes occurred during an early pregnancy, and eventually could save women from conditions that could pose a threat to life as the season goes on.

Scientists developed small boxes using villi cells – small-like-like structures – taken from placental tissue.

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These trophoblast organodes can survive in the long term, are genetically stable and organize them into similar structures that steal essential proteins and hormones that would affect the metabolism of the mother during pregnancy.

While profoundly, scientists found that the organoids were very similar to the usual trimester plates. In fact, organoids are modeling the early plaque as close as possible so that they can record a positive response on a counter pregnancy test.

Professor Graham Burton, co-authorer and Director of the Trophoblast Research Center, who celebrated last year's tenth anniversary: ​​said mini-placentas & # 39; This builds on decades of research and we believe that they will transform work in this area. They will play an important part in helping us investigate events that occur during the earliest periods of pregnancy and yet have intense outcomes for the lifetime health of the mother and race. "

"The placenta supplies all oxygen and nutrients that are essential for fetus growth, and if it does not develop properly, the pregnancy can end with a low birth weight baby or even a dead birth. "

Professor Ashley Moffett said, "Now we have developed both sides of the interface – tissue and mother and placental tissue – we can look at how these two sides talk to & # 39; each other. "

Commenting on the study, which appeared in the Nature magazine, Vivian Li, leader of the Francis Crick Foundation group, called the little organs called "exciting development".

"The ability of this mini-placentas culture in the dish has opened the possibilities for more complex studies," said Li, who was not part of the research.

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