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Latest News in General Practice March 26 2019 (2 of 5)


Billions worldwide have been infected with tropical worms. It 's not surprising that most of these people live in poor countries, being badly affected by malnutrition effects associated with worms. What might be surprising for many people is that worms also cause most cases of some cancers in these countries.

Published in Boundaries in Medicine as a collection of a special article on malignancy associated with parasites, new research seeks to steer prevention and treatment – and perhaps even turn worms against cancer.

Earthworms cause cancer

Over a million species of worms have been classified as helminates. One feature unites them: parasitism. "Helminates are in many forms, but they all harm their host in some way. In humans, they can live in the intestinal tract, the urinary tract, or the blood stream, causing a variety of malnutrition illnesses." to organ failure, "explains co-editor Dr Monica Botelho of the Portuguese National Institute of Health.

In 2015, an increased case of infection gives helminates to the headlines: a man died with HIV / AIDS after his worm cancer was caught and spread around his body. This is the only case of this type ever recorded.

Meanwhile, scientists have known for decades that helminites can turn human cells into cancers. "Three species of helmin are classified as class 1 carcinogens by the WHO," adds Botelho. "These are all designated trematod humanities – after the Latin name for the grisly feed cavity they are tied on their host's inserts."

Cancer associated with worms is not just a fluke – it's three

Tramatites are called flutes & flutes; informally. In this case, however, they're nothing but. "In endemic regions – mainly sub-Saharan Africa and Southeast Asia – liver fluke is responsible for most cases of bladder cancer and liver," said Dr Joachim Richter, link teacher at Charité Berlin and co-editor with Botelho. "Cancers occur in liver fluke infection sites including the bladder wall and liver bile ducts."

But how do worms cause cancer? According to the research collection, their feeding and breeding practices may be to blame. "Worms are wounded and re-wound regularly as they tie in feeding their cavity, digging through organs, and depositing eggs in the bladder wall. This leads to chronic inflammation as the body seeks t improves our endless, lots of cell division and so many opportunities for mutations that cause cancer to accumulate over years of infection. "Then the toxic toilet habits of the worms add insults to injury t . "Worms and their eggs also excrete proteins that worsen this chronic inflammation, promoting further cell division as well as the growth of the blood vessel needed to feed them," adds Richter.

Hyperworm worms protect guests from cancer

Worm infections and early stage cancers are often anymptomatic, so despite the availability of anthelminthic drugs, patients often present too late for curative treatment. Fortunately, the worms have the Achilles heel: they need freshwater snails as the first force before infecting people.

"Worms have been successfully eradicated in Japan through economic development and filling and drainage of snail habitats," Richter said. "There are attempts to disappear in Thailand, which has the highest rates of fluke infection in the world and bile duct cancer – but some high-risk countries like Ethiopia have a coordinated monitoring or prevention program for cancer. 39 n connected with the worm and need more help.

Beyond eradication efforts is another strange world of worms and cancer: helmets as a cure for malignancy. "There are many parasites, including some helmets such as liver fluke Fasciola hepatica, prevents cancer growth in vitro. Another one of these – the worm worm; ominously – is associated with a significantly lower rate of cancer in human guests, ”Botelho said.

"In fact, there is evidence that proteins produced by hyperworms are hyper as well F. hepatica not only killing cancer cells directly – but it could also improve their host's immune response to tumors. "

"Even worm proteins that promote cancer could be re-treated as treatments for other conditions: for example, those promoting new growth in blood vessels could help solve injuries. T chronic non-healing in people with diabetes, tobacco users, and the elderly. "

To read more, click herefcewewsbuxavwvtrca.

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