Thursday , May 26 2022

ANTENA 3 TV | An international scientific study reveals the relationship between pig and lack of attention



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An international study, with the participation of Spanish researchers, has noted dozens of genes that contribute to lack of attention hyperactivity (ADHD) and have developed the first genetic map of this pathology. At work, published by the "Nature Genetics" magazine, more than 80 authors from 60 research centers, including researchers from the University of Barcelona (UB), Hebron Vall Hospital, Mutua Terrassa Hospital and & # 39; r Barcelona Global Health Organization (ISGlobal).

The research has analyzed nearly ten million genomic jobs in more than 50,000 people from different countries in Europe, the United States, Canada and China. After this analysis, which is the first genomic scale study on ADHD, researchers have identified 12 specific parts of DNA that are related to the suspicion of this condition, namely one of the most common psychiatric disorders in childhood and adolescence and affecting around 5% of children and 2.5% of adults.

ADHD is characterized by lack of attention, hyperactivity and stimulating behavior, and restrict the personal and social skills of those affected. With an unknown origin to date, everything indicates that ADHD is the result of the combination of environmental factors (toxicological, psychosocial, etc.) with a polygenic hereditary base (which would explain about 75% of & # 39 ; r chaos).

The work, led by universities of Harvard and New York (USA), and Aarhus (Denmark), has focused on studying and the role of genetic variations in the general population is generally in this disorder. The study has revealed that the common genetic fluctuations "have a 21% weight in ADHD genetics", according to Bru Cormand, the head of the Neurogenetics Research Group at the UB School of Biology.

"Besides," he added, "most of the genetic modifications found to be found in regions of the genome that are stored extensively throughout evolution, which indicates their functional relevance. " In particular, the research has identified twelve genomic divisions, ten of which correspond to specific genes, giving ADHD an idea and found that many genetic changes associated with & # 39; This disorder affects the elements of the expression of genital expression in the brain.

Amongst the extracts identified, the FOXP2 gene stands out – one of the most studied in relation to language development in people – which encodes protein with a prominent role in the formation of synaps and learning neuronal. FOXP2 had already been identified as a candidate gene for ADHD in the 2012 study where several Spanish authors repeated in this new work and is now one of the few genes set out in the science literature that appears in this new map of ADHD.

Another of the specified gene -DUSP6- is involved in the management of dopaminergic neurotransmission, which is a target process for ADHD's most common pharmaceutical treatments. A third gene, SEMA6D, expressed in the brain during embryonic development, could also play an important role in the formation of neuronal branches. The international study has also reviewed the genetic basis shared between ADHD and more than 200 features, both psychiatric and non-psychiatric.

According to Cormand, "the results reveal genetic overlap between ADHD and major depression, anorexia, educational level, obesity, reproduction, smoking or insomnia." According to Cormand, "this study reinforces, against some voices of denial, the idea that ADHD is a strong biological base disorder, where genetics say a lot."

The Catalastic researcher has emphasized "the importance of promoting large-scale studies that is only possible through a large international consortium to examine the genetic basis of the complex brain diseases."

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