Tuesday , August 9 2022

Youth well? Study finds a new anti-aging compound in a plant



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In Japan, a bit bitter leaf of the Ashitaba plant has still been considered healthy, and a new study has found that the traditional belief has a good scientific base.

It seems that a natural substance in the plant leads to a key process that helps to eliminate "rough waste" that can increase as a cell age and cause a range of diseases and disorders.

"It's always nice to find a scientific logic for traditional folk tales," said Frank Madeo, a professor at the University of Graz's Molecular Bioscience Institute in Austria.

Madeo, who helped lead the research, said that the substance known as 4,4 -dimethoxychalcone or DMC, which is naturally occurring in the Ashitaba plants, causes a process of the autophagy name.

"This is a cleaning and recycling process," he told AFP. It eliminates "extreme material, especially the cellular garbage as compound proteins."

The "cleaning" process is a key to continuing good health as the body arrives. When cells fail to dispose of damaged parts promptly and efficiently, they can incorporate and that can lead to diseases including cancer.

A handful of compounds are already known to scientists who work to stimulate the cleaning process. Acceleration also seems to naturally encourage cells to clean up spring.

But in an effort to expand the field of compounds that can protect cells and turn their hands, the team of researchers turned into a class of substances of the name flavonoids.

Many flavonoids have already had a variety of beneficial effects, ranging from anti-inflammatory properties to protect against brain and cancer decline.

The team reasoned that they could find flavonoids that could also help to prevent destructive aging in cells.

180 compounds were screened representing different sub-categories of flavonoids, searching for candidates who may have "natural resistance" to the deterioration of age-related cells. "

After initial screening, they settled on DMC and began to test how the substance affects the leavened cells.

They find that it really helps to protect the yeast cells from the effects of aging, and that the substance performs as well or even better than some compounds that already exist for their protective cell capacity such as resveratrol, which occurs in grapefruit, among other places.

The team then tested the effect of DMC on cells in both worms and fruit flows – common test subjects in medical research.

"Incredibly, chronic DMC treatment … extends the middle life of the two model organisms around 20 percent," said the study published on Wednesday in the Nature Communications magazine.

Additional tests showed that the compound helps to protect cells in the mice hearts through the autophagy process, and even protected from a type of liver damage caused by ethanol drugs.

The team also experienced the impact of DMC on many types of human cells and it was found that the substance was also working to slow down aging.

"The experiments indicate that the effects of DMC could be transferable to people, although we have to be careful and wait for real clinical trials," said Madeo.

The research is still in the early stages and Madeo said that next steps will include testing the positive effects of DMC in mice hearts extending more widely to protect mice against aging and disease age related.

"Ultimately, people need clinical trials," he added.

© 2019 AFP

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