Thursday , May 26 2022

A Chinese scientist behind genetically modified babies defends his research


Speaking ahead of a nice hall of around 700 people at the Second International Genome Human Editing Summit on Wednesday, He Jiankui said he felt "proud" of his work.

He, a professor at the University of South Science and Technology in Shenzhen, claims that his laboratory has meant embryonic genes for seven couples that are in-vitro fertilized, using an instrument called CRISPR-cas9 , which can insert or delete specific genes.

In a video posted to YouTube on Monday, he said, as a result of that intervention, that two prominent healthy twin girls were born with a DNA that had been changed to do resist HIV "a few weeks ago."

"For this particular case, I'll feel proud. I feel proud, because they've lost hope for life," he said, referring to parents & # 39 ; the twins, and it is believed that a father carries HIV.

"But with this defense, he (the father) sent a message saying he will work hard, earn money, and take care of his two daughters and his wife."

Ef Jiankui at the Second International Genome Editing Summit in Hong Kong on November 28, 2018.

The presentation opened by thanking a school, University of South Science and Technology in Shenzhen, "although they were not aware of the study carried out," he said.

When asked for the costs, he claimed he had covered all expenses associated with the patient's medical care in person. He also admitted that some of the progression costs were included by commencement funding from his university.

He said that his research had to submit a scientific journal to review, without naming the announcement and apologized for the result dropping "unexpected".

A Chinese scientist claims the first babies of the generation of the world, during the denial of hospital and international crew

His research has raised serious ethical questions about transparency of genes and inviting calls for global consensus as the speed of genetic editorial technology exceeds the ability to make new laws or regulations.

In a question answer session after the presentation, he said that he had held two circles of informed consent with parents, including explaining that by removing the gene, called CCR5, that the infants could be is exposed to other infections such as West Nile virus, although the informed consent form does not mention this.

Volunteers were found through a voluntary HIV / AID group, he said.

However, many of those present at the Hong Kong conference have indicated that, although there are no global regulations that exclude their actions, its claim of CRISPR-cas9 represents a clear break with a convention.

"There is quite a tight consensus of what is, and is not acceptable, means a genome from now on, and the work that it has reported represents a departure from that," said David R Liu, a chemistry professor and chemical biology at Harvard University, which has pioneered enhancement of CRISPR versions.

The conference, which is attended by leaders in the fields of genetics, ethics, as well as policy makers, is expected to announce a statement on the development during its closure session, on Thursday.

After his presentation, chairman of the David Baltimore conference, said that the research was not necessary medically because there were other treatments for HIV. Baltimore Default criticized transparency itself and referred to an agreement made at the 2015 conference which said that it would be irresponsible to use such genetic editing until safety issues were dealt with.

China is a leading player

China has invested extensively in generation editing technology, with government governing research into a number of worlds "firsts", including the first use of the instrument CRISPR-Cas9 was born among people in 2016 and the first use of gene editing technology to customize incredible human embryos in 2015.

Last year, China recorded 1.76 trillion yuan ($ 254 billion) on R & D, and the country catches up with US investment in the same area, stimulating a labeled genetic weapon race "Sputnik 2.0" by Dr. Carl June, an immunotherapy specialist at the University of Pennsylvania.

However, in a joint statement published on Monday, he condemned over 120 Chinese scientists that he used the CRISPR-Cas9 tool as a "big blast" to the reputation of Chinese biomedical research.

"It's extremely unfair for enthusiastic Chinese scientists, innovative and protecting the bottom line of scientific ethics," they write, adding that "human experimentation is not directly It's just crazy … as soon as a living human is being produced, no-one could predict what kind of effect it will come, as the hereditary substance modified will inevitably match the genom pool human. "

The Chinese government has also ordered a "direct inquiry" to He claims.

The government investigation follows hospital movements that are named in He and the university's associated approval documents, to refuse to take part in the procedures.

In a separate development, on Wednesday, Rice University said he was researching the teacher Michael Bioesi after he was quoted in media reports so that he had been involved in his work.

We were a councilor in Rice for more than three years and had published three papers with him.

"This research raises scientific, legal and ethical questions," said Doug Miller, director of the media relations team of the University of Rice. In a statement, Miller said that Rice had "no information about this work."

Unknown results

At the forefront of global concerns, the gene editing technology is still in its infancy and it could have huge incredible results to use in human embryos that can go on.

Chinese scientists use generation editing techniques for people for the first time

Feng Zhang, one of the inventors of the CRISPR gen editing technique and a member of the Broad MIT and Harvard Foundation has called for a moratorium on the use of CRISPR to mean baby genes.

"He's calling for the field to be more watchdog," he told CNN at the conference on Wednesday. "This is not the things we should do at the moment."

Despite ethical concerns, a recent study suggested that the Chinese public were broadly in favor of using genes for medical purposes. An online survey conducted by Sun Yat-Sen University in Guangzhou found that more than two-thirds of the 4,771 people surveyed (575 of them with HIV) support the use of treatment diseases, according to the Global Times tabloid.

"People (Chinese) have a high willingness to use a gene in preventing and treating illnesses," said Liang Chen, a teacher at Sun Yat-Sen University. "This suggests that the research of gene genes in China does not only have promising potential, but it also responds to the needs of the public."

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