Friday , June 24 2022

Zebrafish helps unlock mystery for motor neurons



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Scientists from the University of Sheffield have succeeded in creating zebrafish that carries the complex genetic change known as causing the most common genetic type of motor neuron (MND) disease.

The increase will help accelerate innovative research and experimental drug trials to tackle degenerative disease.

To date, research to better understand how the disease occurs and experimental drugs have been carried out on fruit insects or mice models. This has been a limited success due to the difference between the human brain and the brain to fly fruit, and the time and cost implications of using mice models.

For the first time, researchers from the Sheffield University's Translation Neuroscience Institute (SITraN) have successfully created complex aspects of human C9-ALS / FTD batobiology in zebrafish models.

This innovative development is essential for studying basic MND and frontotemporal dementia (FTD) mechanisms.

MND, also known as Amyotrophic Multiple Sclerosis (ALS), is a neuro-dangerous disorder that affects the nerve-brain and backbone neurons that tell your muscles what i & # 39; w do.

These messages of these nerves stop slowly into the muscles, leading them to weakening, stiff and ultimately waste. Increased illness affects the ability of the patient to walk, talk, eat and breathe. MND affects 5,000 adults in the UK and there is no improvement at this time.

About 10 percent of MND cases are infected but the 90% of the remaining MND cases are caused by complex genetic and environmental interactions that are not currently understood – this is called intermittent MND.

The most common genetic cause of MND and FTD is the hexanucleotide expansion within the first intron of the C9orf72 gene. In this gene hundreds and thousands of repetitions of the CSSIWS sequence are in patients with MND. This mutation is the largest genetic cause of MND and also the most popular form of intermittent ALS.

Dr Tennore Ramesh, from SITraN at Sheffield University, said: "Using zebrafish models for MND research means that we can accelerate studies and an understanding of destructive disease and other neurological conditions.

"As a zebra is transparent, you can record the results of studies much faster and easier – the research is much less intrusive.

"Piloting 1,000 drugs on mice models would take more than 10 years, but trialing 1,000 drugs on zebravish would take only a few months.

"This will enable us to accelerate research into clinical trials among people faster than ever before."

The four year project, led by Dr. Ramesh in collaboration with leading researchers from SITraN, including Professor Dame Pamela Shaw, Vice President and Head of Faculty of Medicine, Dension and Health at Sheffield University, in the magazine Communication Neuropathologica Acta. The study was funded by the MND Society.


Further investigation:
An animal welfare solution helps to accelerate brain and diabetes research

More information:
Matthew P. Shaw et al, Stableble Transformig C9orf72 zebrafish are key components of the ALS / FTD phenotype and reveal new pathological features, Communication Neuropathologica Acta (2018). DOI: 10.1186 / s40478-018-0629-7

Provided by:
Sheffield University

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