Bank of England has released a list of scientists who have been nominated to appear on the new £ 50 note.
On the list are computer innovators Alan Turing and Ada Lovelace, a source engineer Alexander Graham Bell and astronomer Patrick Moore.
The Bank received 174,112 nominations, and 114,000 achieved the eligibility criteria.
To be on the list, the person must be true, dead and contributed to a UK science field.
The list contains more than 600 men and almost 200 women, including Stephen Hawking's blackhole expert, Alexander Fleming's penicillin detector, father of the modern John Epidemiology, Snowdon, Naturist and Zookeeper's father Gerald Durrell, fossil pioneer Mary Anning, British-Jamaica businesswoman and nursing pioneer Mary Seacole and Margaret Thatcher, who was a scientist before becoming prime minister.
The late Baroness Thatcher studied chemistry at Oxford University and after graduating he joined British Xylonite Plastics in 1947. Two years later he joined J. Lyons & Co at Hammersmith, west of London, as a food research chemist in a role that included quality testing cake-drawings and ice cream, wrote the biographer Hugo Young.
The politician has been credited with devising soft soft ice cream – a product that Lyons worked on – but "there is no firm evidence that Thatcher has helped directly in his device", according to the journalist's article Royal Society.
Book Makers William Hill has Stephen Hawking as the current favorite, with credits of 7/4, followed by Dorothy Hodgkin 4/1 Nobel-chemist followed by.
Ada Lovelace, Alan Turing and Alexander Fleming are in violation of 5/1 and Rosalind Franklin, who made important contributions to DNA's understanding, is 6/1.
Further names will be considered until the nominations close on December 14.
After that the decision will be considered by the Bank Bank Features Advisory Committee.
Paul Rincon, science editor of the BBC News website
The eligibility definition for this list is currently quite broad, but it is likely that strict criteria will be applied once the committees of the Bank consider the names .
So, although Margaret Thatcher's contributions to politics are significant, he still can see if the committee will judge that it is a similarly significant scientific figure.
Here is one of the names that some observers will think outside of some strict scientist definitions. But a broad definition of qualification could help to promote some figures that have been ignored by the organization in their lifetime, such as Mary Anning, who, without formal qualifications, helped to document important fossil finds from southern England.
Those who hope that strong female competitors will find many who like the list. But there are also features that highlight the contributions of ethnic minorities and immigrants to British science.
The short-listing committee will include the space scientist Maggie Aderin-Pocock, the author and genetics specialist Emily Grossman, editor of the British Journal for History of Science, Simon Schaffer, and & Theoretical physicist and Simon Singh particles.
Nominations may include anyone who worked in any field of science, including astronomy, biology, bio-technology, chemistry, engineering, maths, medical research, physics, technology or zoology.
At present there are 330 million £ 50 notes in circulation, with a combined value of £ 16.5bn, the Bank said.
A year ago, there were doubts that the £ 50 note would still exist at all.
Feeling that the greatest denomination note is used extensively by offenders, and ordinary purchase rarely would trigger a government-led debate about whether to abolish it.
The note of £ 50 was described by Peter Sands, former Chief Executive of the Chartered Standard Bank, such as "corrupt currency, offenses of all kinds and tax avoidance".
However, in October, ministers announced plans for a new version of the UK print, which would say that plastic – therefore, would be more resilient, safe and harder to create.
The innovators of the Steam engine, James Watt and Matthew Boulton appear on the current £ 50, which was published in 2011.