Jose Mourinho's side is in the face of Swiss Young Boys Boys tomorrow as they look back from the nest of a nest with Crystal Palace.
But it looks like they will be forced to changes in the back as Victor Lindelof fails to train today.
Swede, an important player for Mourinho in recent weeks, was among a trio of players, including Matteo Darmian and Marcos Rojo to miss the open session today.
Damrmian also made a rare appearance on Saturday with Luke Shaw being stopped, Diogo Dalot and Antonio Valencia were in favor.
However, Rojo has not appeared for Manchester United every season, with a last club game coming on May 13 against Watford in the 1-0 victory.
United States could qualify for the final 16 of the Champions League tomorrow if they win and Valencia does not beat Juventus, so Mourinho will be eager to get his strongest side available.
Lindelof collected a grape injury on Saturday and is almost certainly the game with Young Boys.
Mourinho told MUTV: "I always say that this is the time of the injuries. If they are not injured with national teams, they come to the clubs and get injured.
"He played against Russia three days ago or two days ago, but of course we need it when he plays.
"It's probably the best player she was. She was a brave child, but she probably punished herself. I do not know how long it will be out, but there's a & A great example. "
Shaw should return again after losing the Premier League game while Mourinho will have to choose between Eric Bailly and Phil Jones in the center back.
Mourinho was tired on Saturday, demanding his side throwing two points in their hunt for the top four.
"It was a bad result," he said. "We will say a very bad result. Not a point, two points are lost.
"The objective was that we had eight games up to the end of December to restore our situation, to get points, to reduce the distance, to reach the top four, but at the end we got two points.
"We gave time to breathe because we were not intense and intense and intense. We lost the ball, we gave time to breathe and then we were waiting for things to happen and things did not happen."