The Spaniard has been using a four-back fullback lately, but may return to a three-man defense this afternoon given Spurs’ attacking talent.
Either way people like Gabriel Magalhaes and Kieran Tierney will come to the side, while David Luiz and Rob Holding are pushing to join them.
Dani Ceballos and Granit Xhaka are the favorites to start in midfield after resting Thursday against Rapid Vienna, but Mohamed Elneny and Joe Willock push them.
At attack Bukayo Saka and Pierre-Emerick Aubameyang return and could be joined by Alexandre Lacazette.
Arsenal line-up (3-4-3) predicted: Leno; Holding, Gabriel, Tierney; Bellerin, Ceballos, Xhaka, Saka; Willian, Lacazette, Aubameyang.
Today 4.30pm GMT, Sky Sports
Location: Tottenham Hotspur Stadium
Arsenal squad from: Leno, Macey, Runarsson; Bellerin, Cedric, Chambers, Gabriel, Hold Luiz, Mari, Mustafi, Saliba Tierney; Azeez, Ceballos, Cottrell, Maitland-Niles, Partey, Smith Rowe, Willock, Xhaka; Aubameyang, Balogun, Nelson, Nketiah and Lacazette.
Doubts: Luiz (pen) and Partey (thigh).
Injured: Martinelli (knee).
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