Blockbuilding combats happiness
Laughter is the best medication – it's still claimed to be popular. No wonder, because of those who laugh happily and who are happy, release happiness hormones. Recently, an international research team came to find that one of the Construction blocks of Happiness hormones really strengthens our immune system and even contributes to the fight against diseases.
Researchers of the Institute of Molecular Biotechnology at the Austrian Academy of Sciences (IMBA) and Boston Children's Hospital in Harvard recently showed a new way to fight autonomous, asthma, allergies and even cancer. The focus of the research is a building block, where the body produces serotonin and dopamine happiness hormones. The study team found that this building block also operated immune system protection cells. The results of the work have recently been published in the famous "Nature" magazine.
What do killing cells and happiness hormones are common?
The single cell killer (T cells) of a immune system as well as serotonin and dopamine need the same construction block to work. The international research team of the tetrahydrobiopterin happiness hormone molecule (BH4) identified as the base operator of our protective cells. "The interesting thing about our discovery is that a system called really in neurobiology can play such a vital part in the T cell immunity protection," said IMBA Director Josef Penninger in a press release.
Fight independently against cancer
Recently, what the body can show it has to show by a new method that a immune system itself will be functionally functioning to fight cancer cells in the body independently. These findings were honored with the Nobel Prize for Medicine. In order to deepen their understanding of immune protection, its operation, and the metabolic processes involved, the Penninger team studied closer immune cell biology and identified new possibilities for multi-purpose medical applications.
Possibilities of a completely new and wide application
"This new approach connects two completely different systems in our body and unlike all of the previously identified immune checks," says Penninger. This opens a wide range of therapeutic options that can be used, for example against inflammatory bowel disease, asthma, multiple sclerosis, arthritis, allergies, skin diseases or cancer.
BH4 makes soldiers of the immune system ready to fight
Scientists are known to BH4 for some time. It is known that the molecule is associated with numerous metabolic processes. What's new, however, is that BH4 also manages the growth of T cells that act as "soldiers of a immune system." According to the researchers, this process occurs through iron metabolism. This is also the reason why people with a lack of iron or anemia often suffer from immune problems.
How our immune system works
The IMBA research team clearly explains the immune system protection process: "T cells patrol our bodies and reveal pathogens or to tone cells that may become tumors." When it comes to such a meeting, the T cells will pass through the BH4 After operation: it starts to multiply and begins to fight. However, this could lead to misinterpretation, since incorrectly functioned T cells began to attack the body's own cells. This event can cause allergic reactions and automatic diseases.
Management has to target the immune system
"Automatic diseases and allergies are among the most common emerging diseases around the world and urgently needed," Penninger emphasizes. In the new autonomous disease approach, BH4 has targeted to be stopped so that T cells are not set in a consistent assault method. As a result, they would not destroy healthy tissue or cause chronic inflammation. The first clinical trials of the new QM385 drug, which is said to stop BH4, are already in the starting blocks.
The process is reversed to combat cancer
The reverse is true with cancers, where BH4 can help the immune system to better identify and target cancer cells. Initial exams on mice have already shown that BH4 helps the shells to fight tumors. "If you succeed in finding cross-links with different biological systems in the body, as in this case the nervous system and the immune system, sometimes you can make incredible finds , "summarizes their findings to the research team. (Vb)