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Adverse pregnancy results can result from a higher BMI pregnancy


Women with hypertension or obesity are at greater risk of fetal loss and spontaneous abortion than mothers with lower weight status, and their babies have a higher mortality rate, according to the findings published in Wales. Obesity.

“Despite the significant increase in maternal and child health over the last few decades, there are still concerns about stillbirth and neonatal death and babies, particularly in low and middle income countries,” Jianmeng Liu, PhD, from the epidemiology and biostatistics department at the School of Public Health at Peking University Health Science Center in Beijing, and colleagues. “More information on the comprehensive effects of maternal obesity and under pressure on adverse pregnancy outcomes is a public health priority.”

Liu and colleagues assessed pregnancy results in 18,481 women (median age, 23 years; median BMI, 21.9 kg / m).2) took part in a trial for a nutritional supplement between 2006 and 2009 in Hebei province in China. On average 12 weeks of pregnancy, each participant's BMI was calculated. Researchers defined obesity as a BMI of at least 27.5 kg / m2, overweight as BMI of 23 kg / m2 to less than 27.5 kg / m2 and under pressure as a BMI of less than 18.5 kg / m2

The researchers found that 71 early neonatal deaths, 87 neonatal deaths, 134 infant deaths, 651 spontaneous abortions and 82 stillbirths were in the cohort. Children of mothers who had obesity had the highest mortality rate (6.3%) compared to those with overweight (4.7%), normal weight (4.5%) and underweight (4.9%) t .

After adjusting for mother's age, educational level, occupation, age of pregnancy, hemoglobin and the nutritional supplement used in the original study, the risk of fetal loss was highest for women with obesity (RR = 1.51; 95% CI, 1.15-1.99) and overweight (RR = 1.21; 95% CI, 1.03-1.42) compared to normal weight. A similar high risk was found for spontaneous abortion for women with obesity (RR = 1.51; 95% CI, 1.13-2.02) and overweight (RR = 1.25; 95% CI, 1.06-1.48) compared to normal weight. Mothers with obesity were more likely to provide a premium (RR = 1.59; 95% CI, 1.25-2.02), with newborn babies with macrosomia (RR = 3.71; 95% CI, 3.01-4.59) and introducing children who were large for pregnancy age (RR = 2.93; 95% CI, 2.49-3.47) compared to normal weight mothers. Overweight mothers were also at higher risk for premature delivery (RR = 1.27; 95% CI, 1.11-1.45), newborn babies with macrosomia (RR = 1.88; 95% CI, 1.61-2.19) and delivery of children. for pregnancy age (RR = 1.74; 95% CI, 1.55-1.95) compared to normal weight mothers.

At the other end of the spectrum, children of lower weight mothers were at higher risk for early neonatal death (RR = 2.17; 95% CI, 1.06-4.45), perinatal death (RR = 1.9; 95% CI, 1.14-3.18), being small for pregnancy age (RR = 1.69; 95% CI, 1.44-1.98) and having low birth weight (RR = 1.56; 95% CI, 1.11-2.18) compared with children of mothers with normal weight.

“These findings confirm the importance of appropriate weight before and during pregnancy for the child's health,” the researchers wrote. – by Phil Neuffer

Disclosures: The authors do not report any relevant financial disclosures.

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