The prevalence of atopic diseases is increasing in the modern world, and atopic dermatitis is a disease that occurs in early childhood. From an epidemiological perspective, around 20% of all children develop symptoms of atopic dermatitis at some point in their lives, half of them in the first year of their life. Atopic dermatitis occurs in 95% of children under 5 years of age.
– Atopic dermatitis is a skin condition that is not always easy to understand because it has a direct impact on the child's everyday life and family. Our chronic skin condition is characterized by dry, irritated skin, and inflammatory skin changes. It is often associated with the family history of the disease, Dr. Milosevic.
Atopic dermatitis cases can be genetic immunological. Around 30% of all children with atopic dermatitis have a food allergy, particularly milk and eggs, but also soy, wheat, peanuts and fruit. A child with moderate to severe dermatitis has a 50% risk of developing asthma, and in children the risk of developing pollen allergy is as much as 75%.
– Today it is known that atopic dermatitis may be associated with dysfunction of the function of the mucous membrane of the bowel. Moreover, the composition microbot of the intestine it may be different from people with atopic eczema than those without this condition, and differences of this kind can occur before eczema development, says Dr Katarina Milosevic.
There is also an increasing number of evidence referring to the vital role of colonization from the organs developing t immune system. The possibility of adapting the digestive tract in childhood can prevent atopic diseases occurring. Studies carried out to date on the treatment of atopic patients with food allergies suggest that renewing the permeability of the intestinal mucosa, by modulating the local immune response, is possible to restore the changed immune activity.
– A number of studies conducted in the meantime have shown that probiotics It can operate three times, on the right cause of the disease, then, as a very useful complementary therapy, and ultimately as a good deterrent of the disease, says Dr Katarina Milosevic.
In one of the first studies on this topic, in babies who are allergic to cow's milk proteins, fecal confidential IgA concentrations were higher, TNF-lower, in the LGG-administered group compared to placebo. In the following studies on this topic, the density and spread of rash and subjective symptoms were shown to have decreased significantly in children with atopic eczema using probiotics which included t Lactobacillus.
In another clinical study Gctobacillus GG during breastfeeding, and during breastfeeding for mothers who had at least one relative (or partner) with atopic eczema, allergic rhinitis, or asthma, and postnatal, during 6 t month of baby development. The frequency of atopic eczema in the probiotic group was half as low as the frequency of a group of babies without probiotics.
The interesting question is whether the development of allergic diseases in early childhood can be prevented by intestinal microbiota modulation. probiotic bacteria?
– In recent years, more and more research is underway on the new role of probiotics. It's about their effect on the work of the immune system. By applying them, the integrity of the intestinal barrier is restored, preventing the passage of allergens and pathogenic bacteria through the mucous membrane of the bowel, emphasizing Dr. Milosevic.
Impact of probiotics on prevention and elimination allergies is the subject of a study of numerous studies, and it is supported by a mechanism that has not yet been fully understood. A microbial bowel affects the development of the immune response and cell type balance (Th1 / Th2), which in turn determines the development of oral tolerance. The Th2 type immune cells produce IL-4, which is necessary for the differentiation of B cells in the cells produced by IgE, and IL-5, which is important for ezinophiles and lymphocytes activity. This is why they have a particularly beneficial effect in allergic diseases, such as allergic rhinitis, bronchial asthma, food allergy, particularly cow's milk protein.
This is borne out by the findings of a number of studies suggesting that microbiota are different from children who tend to have allergies and have fewer bifidobacteria in the intestines, and in particular t Lactobacillus, compared to healthy children.
Studies conducted with Gctobacillus GG or with other probiotics given to pregnant women between 2 and 4 weeks before delivery, followed by treatment for up to 6 months with the same probiotics, which resulted in lower rates of atopic dermatitis in the first 2 years of their life, t compared to placebo.
A number of meta-analyzes aimed to evaluate the impact of probiotic use during pregnancy and early childhood in the prevention of atopic diseases. The results of new meta-analyzes have shown that probiotic additions prevent infantry eczema, indicating a possible new sign for use probiotic during pregnancy and early childhood.
Finally, it is important to remember that bacteria are transferred from the mother to the child at birth, and that there are signs that the microbial of the atopic baby tubes are different from the microbiota of the baby. healthy babies. In early childhood, the development of asthma precedes microbial bowel conflict and metabolic dysfunction.
– Moreover, that was proved Gctobacillus GG increases the growth of bifidobacteria in newborn babies, and in adults who are overbearing to milk. That was proved use of probiotics in allergies significantly reduces the symptoms. They can also get preventive, if one or both parents have some sort of allergy, says Dr Katarina Milosevic.