Saturday , July 2 2022

Researchers reveal the secret of immune response with slaughter diseases


Experts confirmed that our immune responses were controlled by the body's biological clock throughout the day, making the disease more severe for those who had infected at certain times of the night. Day.

The biological clock controls the body's 24-hour immune responses, regulating sleep and waking regularly, called a sleep / wake cycle.

In Switzerland, researchers analyzed a series of studies, particularly in mice, and found adaptive immune responses under biological control and discovered four different cases which were more common at certain times of the day: heart attack , pneumonia, parasitic infections, and asthma attacks.

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– Heart attack: in the morning

The findings, published in the magazine Trends in Immunology, show that a heart attack is more common in the morning and tends to be more serious than night.

The number of white blood cells resistant to bacteria, viruses and fungi, which are high during the day and at night, is high in dead heart tissue, which means there is not much cardiac protection at the time compared to the morning.


– Pneumonia: Afternoon

The researchers found that the bacterial poisoning associated with pneumonia started an inflammatory lung response of mice in the afternoon, and the researchers noted that immune cells could recruit more white blood cells in the peritoneal cavity, t the spleen and liver in the afternoon, That time.

– parasitic infections: with night

The results showed that parasitic infections were also time dependent. Studies in rats infected with intestinal parasites "Trichuris muris" in the morning were able to kill worms more quickly than infected mice with night.

Experts say they have found airway inflammation in mice, which may be associated with an increased risk of asthma attacks with night. The leading author Christoph Sherman, an immunologist at the University of Geneva, has the results "impressive", adding that "they must apply to clinical applications."

In humans and mice, researchers noted that white blood cells vary every day on a 24-hour basis. This raises the question of whether one day is possible to improve the immune response through consciousness. The methods of using the biological clock.

"Investigating circadian rhythms in intrinsic and adaptive immunity is a great tool for understanding physiological interactions in general and the sequence of events that depend on time when producing immune responses," Sherman said. "The challenge is how to lead our growing understanding of daily immunology to therapies that have been specially tailored for human beings" t

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