Thursday , August 11 2022

Doctors have learned how to destroy the most common human virus


MOSCOW, February 22 – RIA News. Molecular biologists from the US have created "Frankenstein" antibodies capable of identifying and destroying cells that have been infected with cytomegalovirus, whose carrier is every second person. The first results of their experiments were disclosed in the Journal of Biological Chemistry.

"Now we have a molecule in our hands like antibodies, but it can link to cytomegalovirus proteins that T cell receptors usually bind. The common antibodies do not have this capability, so their creature is a fulfillment so great for us, "said Jennifer Maynard from the University of Texas in Austin (USA).

Cytomegalovirus (CMV) has long been considered in the "successful" virus that affects people. More than half of adults aged 40 or over are infected with this pathogen, which continues to remain in their body throughout their lives.

Usually, the infection is asymptomatic, but if there are problems with the immune system, the cytomegalovirus infection can be fatal, and, as genetics have recently discovered, develop brain cancer. So, biologists from all over the world began to look for ways to destroy.

Maynard and his colleagues made a big step towards creating a vaccine for cytomegalovirus, highlighting one simple thing. The main "conductors" of the immune system, the T cells called traces, can find the traces of this virus in some cells and destroy them, sending them a sign of self-destruction.

Antibodies, for unknown reasons, do not have a similar ability. This stimulated scientists to create a type of "Frankenstein" molecule that could simultaneously find viruses, like T cells, and stick firmly to them, as antibodies do.

Led by this mind, scientists were transplanted into the T-cell genome that is responsible for cytomegalovirus receptor assembly to a special hamster cell culture genetics uses to "grow" overseas proteins.

At the same time, genetics have made many random interventions in this part of the DNA, hoping to have a version of such a "counterfeit" receptor that would connect more firmly with the pathogen or common T cells.

Not experimenting in this way, scientists "transport" this molecule increased by 50 times, and then added the most successful version of the DNA and encoded it to another part of & The genom that is "conventional antibodies" generates conventional antibodies. As a result, the hamster cells began to produce "Frankensteins" which are similar to the T cell receptors and the antibodies.

Such molecules can be used, as scientists point out not only to destroy cytomegalovirus, infected cell marking, but also to fight brain cancer and to learn the secrets of its appearance.

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