Thursday , July 7 2022

Changing pressures in old age is associated with an increased risk of dementia



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flickr.com / okinawa-soba


Korean scientists have found that, in old age, a significant change in weight (more than 10 percent of the body mass index) increases the risk of developing dementia by 20 percent: in the case of weight loss and weight gain. These results are scientists whose article is published in Open BMJ, obtained by analyzing data on more than 67,000 Koreans between 60 and 79 years.

In most studies, body mass growth is viewed from the negative side (for example, as a factor that increases the risk of developing diabetes), and a reduction is considered positive. At the same time, some medical works show very negative effects in terms of weight loss, particularly in old age: in 2018, for example, scientists have found that weight loss of nine kilograms or more is associated with a significant decline in women over 68 years. risk of premature death.

At the same time, a number of studies also show a link between overweight in old age and the risk of dementia, but data to link the body mass index and the relative risk of developing & t This neurodegenerative disease has been enough. Scientists decided to repair it under the leadership of Susan Park (Susan Park) of the National University of Kyonbuk. Data was studied on 67219 Koreans between 60 and 79 years of age: scientists collected information about their body mass index twice – in 2002–2003 and 2004-2005. In addition, scientists gathered information on gender, age, socio-economic status, physical activity, smoking, alcohol consumption, the presence of dementia, as well as cardiovascular diseases and obesity at the start of observations. All data collected was considered in the analysis as side variables.

In terms of dementia development, scientists collected additional data from 2008 to 2013: during this period, the disease was diagnosed in 4887 women and 6685 men. Despite the fact that the initial body mass index was not associated with an increased risk of dementia, its change by more than 10 per cent (increasing and decreasing) was associated with a 20 per cent increase in the risk of dementia. to compare with those participants in the study. his weight remained stable. Interestingly, the risk of weight change did not increase if the initial body mass index was less than 18.5 kg / m2.

Scientists also examined the impact of all variables studied on changes in the risk of dementia. Therefore, the risk of developing dementia increased smoking and high blood sugar levels, while regular physical activity reduced it.

Despite the large sample and carefully considered scheme, scientists do not provide accurate answers as to why weight loss and weight gain are associated with the risk of dementia. Recruitment and weight loss among research participants are probably related to specific medical conditions or unhealthy practices. Nevertheless, scientists insist, with a sudden change in weight over a short period of time in old age, that special attention needs to be given to the prevention of dementia.

In the autumn, scientists found that the risk of developing dementia within ten years can be reliably predicted by three factors: gender, age, and variant of the APOE gene, encoding the apolipoprtein protein E.

Elizaveta Ivtushok

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