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CBD Offers 'Significant Pledge'; for Bondage Heroin



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An oral cannabis solution (CBD) reduces appetite and anxiety in individuals with a history of heroin abuse, with effects lasting a week after the last administration, and can be a non-opioid option to help break a cycle t continued dependency, researchers say.

CBD holds a "significant pledge" for treating individuals with heroin use disorder, leading researcher Yasmin Hurd, PhD, from the Department of Psychiatry and Neuroscience at Icahn School of Medicine in Sinai Mountain in New York City Medscape Medical News.

"The particular effects of CBD on lust and drugs caused by cues are particularly important in the development of addiction therapeutics because environmental queues are one of the strongest triggers for relapse and continued drug use," said Hurd, who also director of the Institute Dependency in Mount Sinai.

The online study was published today in the. T American Journal of Psychiatry.

Long Stay Impact

In indigenous work in animals with a history of heroin self-administration, Hurd and his team at Mount Sinai found that CBD had reduced the trend of animals to use heroin in response to a drug-related queue.

The double-blind placebo trial, randomly, involved 42 adults with heroin use disorder. About two-thirds (64%) had resisted heroin for less than 1 month, 14% for 1 to 2 months and 21% for 2 to 3 months. Most participants had a history of alcohol and cannabis misuse and tobacco use.

Participants were randomly allocated to 400 or 800 mg of oral CBD answer (Epidiolex, GW Pharmaceuticals) or equivalent placebo given once a day for 3 consecutive days. Then they were told about neutral cues and heroin over three sessions: immediately after administration, 24 hours after CBD administration or placebo, and 7 days after the third CBD or the placebo daily administration or. final plasma server.

Consistent with the literature and expectation, the scores were increased for craving on the analogue visual scale for craving (VAS-C) and anxiety scale VAS (VAS-A) concern with exposure to images of heroin equipment but remains largely unchanged when exposed to neutral queues.

Across all sessions, those who received plague reported much more desire after the drug queues (mean difference score 0.93) compared to those receiving CBD 400 mg and 800 mg (mean difference score 0.44 and 0.23, respectively).

There was no significant difference between scores between the groups of participants administering the two CBD doses, indicating that both doses were as low as lust.

In contrast to placebo, CBD reduced anxiety and anxiety significantly triggered by seeing pictures of heroin equipment not only after the administration, but also a week after the final CBD dose.

This supports a recent animal study showing CBD's extended effects on drug searches (alcohol and cocaine) and anxiety-like behaviors 5 months after its short-term administration.

"This long property of CBD would have significant clinical implications, particularly for patient populations where the attachment of daily medication could be challenging," the authors write.

CBD also reduced the physiological measures of stress caused by heroin, such as heart rate and salivary cortisol levels. The CBD administration on the doses experienced had no significant effects on cognition, and was associated only with mild adverse events. There were no serious adverse incidents, consistent with previous reports.

Hurd said her team was working on additional studies to "understand the mechanism of CBD effects on the brain and will do neuroimaging studies to see what the neural circuits the CBD is working on to reduce cravings and anxiety. important count out the correct dose and dosing regimen. "

Need more evidence

Comment on the findings for Medscape Medical NewsJonathan Avery, MD, director of addiction psychiatry at NewYork-Presbyterian Hospital and Weill Cornell Medicine in New York City, said, "CBD products are everywhere and are touched on everything, and so we need good clinical evidence on how to & # 39 'w use and on what dose, etc. This article helps to add to a small group of literature that can help us lead in moving forward.'

Support was provided to the study by GW Pharmaceuticals and through funding from the Icahn School of Medicine in Mount Sinai. The authors and Avery have not disclosed any relevant financial relationship.

Time J Psych. Published online May 21, 2019. Abstract

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