Tuesday , January 19 2021

High-fructose corn syrup stimulates the growth of intestinal tumors in mice



By Aspec

High fructose corn syrup stimulates the growth of intestinal tumors in mice Does sugar directly feed cancers, boosting their growth? It seems that the answer is 'at least', at least in mice, according to a study led by researchers at Baylor Measuring College and Medicine Weill Cornell; in the United States. Their study showed that eating a moderate daily amount of fructose high corn syrup, equivalent to people drinking about 12 ounces of sugary drink a day, accelerates the growth of intestinal tumors in the disease mouse model. regardless of the world of obesity.

High fructose corn syrup stimulates the growth of intestinal tumors in mice High-fructose corn syrup stimulates the growth of intestinal tumors in mice The team, whose work was published in Science magazine, also discovered the mechanism by which drinks can be consumed. sugar-rich feeding of cancer growth directly, suggesting possible new therapeutic strategies. "An increasing number of observational studies have raised awareness of the link between drinking sugary drinks, obesity and colon cancer and rheumatism," said co-author Jihye Yun, assistant professor of Molecular and Human Genetics at Baylor.

"The current idea is that sugar is mainly harmful to our health because excessive drinking can lead to obesity. We know that obesity increases the risk of many cancers, including colon cancer. T and the rectum, but we were not sure that there was a direct and occasional connection between eating sugar and cancer, so I decided to get to grips with this important question when I was a postdoctoral fellow in the Dr. Lewis Cantley's lab 'Weill Cornell Medicine,' he said.

First, Yun and his colleagues produced a mouse model of early stage colon cancer where the NPA gene is removed. "The NPA is a custodian of colon cancer and rectum. The removal of this protein such as removing car breaks. Normal bowel cells do not give the best to grow or die, forming tumors in the early stage of the name of polyps, more than 90% of patients with colon cancer and the rectum have this type of APC mutation.

When the researchers provided the sugar-filled drink in the water bottle so that the APCs could drink in their will, the rodents weighed quickly for a month. To prevent mice from being obese and mimic the daily use of soda in humans, the scientists gave them a moderate amount of sugar water verbally with a special spray once a day. After 2 months, the NPA model mice that received sugar water were not obese, but larger and larger tumors developed than the model animals treated with normal water.

"This comment in animal models could explain why the increase in the use of sugary drinks and other high-sugar foods in the last 30 years is correlated with an increase in colorectal cancers in 25 to 50-year-olds. "Cantley, associate co-author, Yun exoror and Cancer Biology Medicine teacher and director of the Sandra Cancer Center and Edward Meyer said 'Weill Cornell Medicine.'

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