Saturday , July 24 2021

Parkinson's disease can start in the appendix



Parkinson's disease was considered long in the brain disease, but a number of studies have referred to the role of the digestive system. A study published on Wednesday in the United States has a special interest in the appendix that the small body is deemed unnecessary.
The authors of this study, based on medical data of 1.7 million Swedau for about half a century, found that those who had had the attachment were removed early at risk of development Parkinson's disease decreased by 19%. It appears that the impact is specific to Awtians living in rural areas. For them, the risk is reduced by 25%, while in urban areas, a risk reduction could not be observed.
For those who developed Parkinson's disease, researchers found that an attachment (attachment removal) was linked to an average average of three and a half years earlier, lead author Viviane Labrie, from the Research Institute Van Andel in Michigan, during a conference call with the press on Tuesday.
"Our work suggests that the attachment could play a part in the start of Parkinson's disease," he explained, stating that this role was not limited.
Parkinson's patients also suffer from gastrointestinal problems, such as constipation, decades or more before symptoms such as roaming and other problems. This has triggered the scientific community to take an interest in the role of the digestive system.
The attachment is a storage site for bowel bacteria and it also appears to be part of the immune response. It is also a "pool" of a key protein in Parkinson's disease, known as alpha-synuclein, especially in abnormal form.
But this protein is extensive in the attachment of everyone, ill or not. This suggests to researchers that the unusual protein was sometimes able to escape the attachment to the brain, where it would cause damage.
"This protein does not like to stay in one place," said Viviane Labrie. "It's going to move from neurons to neurons".
And exactly, a nerve, the vagus nerve, connects the digestive tract to the brain. Experiments have shown that the protein can take this route.
"If it's going to the brain, it can fit and develop until it has neuropathic effects that could lead to Parkinson's disease," said the researcher.
The study authors gave a warning to the press that it was not a matter of recommending everyone to get rid of the attachment. "We do not say, if you've got rid of, you will not get Parkinson's disease," Viviane Labrie warns.
But this work gives a further indication of the role of the small organ, which could one day lead to therapies, to neutralize this fund.
For the minute, a case-effective relationship has not been established. As with studies of this type, many factors may not be taken into account in explaining the difference between those who were excluded and others.


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