Professor Kim Kyung-gyu from Sungkyunkwan University of Medicine School / Director of the Therapeutic Research Team Resistant Antibiotics and Professor Lee Seung-hon from Southampton University, UK has a substance of the name zanthoxylerol and derivatives of & # 39 This substance, The researchers found that they could find effective substances for the new concept of anti-toxic infection treatment without objection.
Antibiotic resistance is one of the ten risks to human survival (the SWF 2018 Sweden report) and urgent solutions are needed. The British Parliament report, published in 2016, warned that more than 10 million people in 2050 could be killed by resistant types unless an antibiotic collision solution was provided. Therefore, antibiotic resistance is one of the tasks that must be resolved for humanity survival.
Antibiotic resistance is a natural and inevitable process inevitably inevitably by adapting to a bacterial injection for antibiotic that directly kills bacteria. Therefore, antibiotics that have an activity of killing the bacteria are inevitably used. Therefore, a completely new mechanism of antibiotics is needed to avoid the production of resistant bacteria.
The researchers found that a substance of the name zanthoxylerol, which is made of chrysanthemum, prevents synthesis of Virphorus factors Staphylococcus aureus, which is one of the typical resistant bacteria, and that the bacteria which causes the infection to be killed through immune action without causing the disease. In addition, we have found a method of synthesizing this substance by organic chemistry and synthesized various derivatives to have PM56, a antioxidant substance possessing better properties than zanthoxylerol. As PM56, which has an anti-toxic activity, does not kill bacteria but is only toxic, it is possible to prevent the production of anti-toxic anti-toxic antibiotic bacteria by not applying the pressure of resistance to bacteria. In other words, it acts as a new concept of antibiotics with antiseptic activity as opposed to antibacterial activity.
It is said to be a healthy food because it has a variety of medicinal effects such as the myth that it can be fresh when it is eaten. The scientific name (Angelica utilis) is also called a very useful plant, which means "a gift given by an angel." Through this study, it proved that kwakchoi can have an antibiotic effect due to antibacterial toxicity.
Professor Kim Kyung-kyu said, "By checking a new antibiotic success that prevents toxicity, we can expect to develop a new infection without resistance."
Professor Lee Seung-here said, "We have solved the problem of low accessibility to substances, the biggest disadvantage of natural materials, through synthesis, and we have set the basic work for developing derivatives with better efficiency. for solving the antibiotics resistant problem, the biggest challenge of the study, "explained the significance of the study.
This study was carried out in conjunction with Tea Bay Teacher – eight from the University of Indiana, Professor Ryu, Kyung – Korea Foundation of Science Research Institute, and Gyeongsang Ki-hoon University.
This research was carried out by the Ministry of Science and Technology, the Ministry of Information and Communications, the Korea Research Institute's bio-medical technology development project and the UK Wellcome Trust. Journal Journal of Chemistry Journal of Chemistry Journal Journal November 15 as an ASAP article.
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