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Discover enteritis cases with small chips to simulate with human shock: Dong-A Science



November 09, 2013 03:34

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Long-term slip developed by the Texas State University research team and Professor Kim Hyun Joong. The intestinal epithelium grows to form the intestine. Experiments are carried out by spraying the culture and drug medium. - Presentation by photographer Professor Kim Hyun Joong

Long-term slip developed by the Texas State University research team and Professor Kim Hyun Joong. The intestinal epithelium grows to form the intestine. Experiments are carried out by spraying the culture and drug medium. – Presentation by photographer Professor Kim Hyun Joong

The mouse that suffers from ulcers is eventually blended with feces and blood. It is enteritis. Feeding a drug from the DSS name to a laboratory mouse may cause enteritis. I'm sorry, but it was an animal experiment that I had to do to know the cause of the disease.

In the future, such things are expected to disappear. The reason because the experimental equipment & long-term chips & # 39; which grows human cells instead of animals and puts them into a piece of plastic with only thumbnails developing day-to-day. Now it's a bit to find out the cause of the disease without animals.

The main character of this technique is a graduate student who wanted to reduce the number of patients suffering from enteritis and a teacher who developed the long-term emitting chips six years ago. A enteritis case was discovered using long-term chips developed internally, without an experimental animal, and published in October of the journal, National Academy of Sciences (PNAS).

Shin Woo Jung, a researcher at the University of Texas in Austin and a team of teacher Kim Hyun Joong, produced two layers of long-term chip chips using accurate filters. In the upper layer, epithelial cells of intestinal cells (cancer cells) that do not die but continue to increase are inserted into the inner bowel environment, including the similar structure to villus . Epithelial cells were tightly tight to each other, and in the lower layer, isolated immune cells were raised to create a mimic and pipe environment blood outside the intestines.

(Left) and Professor Kim Hyun-jung from the University of Texas, USA. - Presentation by photographer Professor Kim Hyun Joong

(Left) and Professor Kim Hyun-jung from the University of Texas, USA. – Presentation by photographer Professor Kim Hyun Joong

The DSS researchers examined the top layer of chips, completed in this way, to cause enteritis and confirm the start of the disease. At an e-mail interview, Professor Kim said, "We checked a combination of long-term chips for each of the intestinal micro organisms in the event of the inflammation, either the cell assault Imagine is activated to be the problem, or is the problem that has fallen the epithelial cell obstruction. "The most fundamental reason for the study is that the epithelial cell wall barrier, which had originally been installed, had released it, "he said.

Original bowel epithelium cells are strictly bound to protect inside and outside the bowel & # 39; without wipeing. However, as a result of the study, should the enteritis develop, interfere with the contact tissue and a hole formed, and external bowel micro-organisms raised the external blood vessels through the hole and met with immune cells, causing problems. Previously, it was assumed that DSS would destroy epithelial cells, but also confirmed that the main reason was not to destroy the cells themselves.

Practical guidelines for treatment and symptom relief were also found. Probiotics, which means that body-friendly micro-organisms, such as lactobacilli, have a good effect on the original intestines. However, the research team confirmed that when the bowel walls are broken and that lactic acid bacteria are timed, these micro-organisms discharged out of the intestines and became more problematic. Serious sepsis was also made. When the bowel wall has seriously injured, it requires careful prescription of lactic acid bacteria.

The long-term chip structure developed by the new researcher and Professor Kim's team. Based on the middle filter, epithelial cells are located on the upper side and blood immune cells have located on the lower side. The experiments are conducted through the medium of DSS's transmission and transmission culture through each channel. - Presentation by photographer Professor Kim Hyun Joong

The long-term chip structure developed by the new researcher and Professor Kim's team. Based on the middle filter, epithelial cells are located on the upper side and blood immune cells have located on the lower side. The experiments are conducted through the medium of DSS's transmission and transmission culture through each channel. – Presentation by photographer Professor Kim Hyun Joong

The study was the first in the world to identify cases and processes of disease cases using long-term chips. "We intend to develop long-term chips using individual cells and cell cells to develop chips that are specifically for patients that reflect individual genetic and environmental factors," said researcher. For a study of bowel micro-organisms, we intend to grow bowel micro organisms that have separated from patients' lips on long-term chips. As well as enteritis, it could be applied to colorectal cancer or inflammatory bowel disease (IBD), the new researcher said.

The study was funded by the International Institute for Ethical Experiments (IFER) and the Korean Research Institute. IFER supports alternative studies to replace animal experiments.

November 09, 2013 03:34

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