Without Declan Rooney
Connacht must plan without the two Bundee Aki and Kieran Marmion for the next games after their heroes with Ireland.
Marmion faces three months on the left after surgery on his ankle injury, while the Aki center has been granted permission from Connacht and IRFU to return to New Zealand for his marriage.
No one will be available for both European parties against Paddy Jackson's Perpignan next month although Aki is expected to be back in time to face Leinster in the RDS in the week before Christmas .
"We're proud to have Bundee back but it needs to have a break of IRFU duties, which will be over this next phase," said coach Andy Friend's coach.
However, Marm's absence is more serious to Connacht. With Conor Murray confined by injury, Marmion hit her scissors before the Six Nations, but now faces a race to prove her fitness in front of their competition against England on 2 February .
Originally, Marmion raised the injury in the Connacht award against Ulster last month, but worsened playing for Ireland against Argentina, and then played an hour against New Zealand a week later.
"Ef [Marmion] is a difficult person. It was big focusing and being driven for New Zealand's performance, which you could see in his eyes as he built up. He knew there was an opportunity there and he certainly secured the evening. I believe it's just a taste of things to come from. It's a quality and it's hard and it has all the resilience and quality you want from a player as well as the skill set. The important thing for him now is to get it stable and return as fast as possible. James Mitchell is now getting a chance and it's also a very important time. "
Connacht opens their two South African tour on Sunday when they take Kings Kings Isuzu, before they go on to meet the Cheetahs six days later. According to the squad Gavin Thornbury follows his two-month cancellation with shoulder injury. Paul Boyle (shoulder), Peter McCabe (headteacher) and Matt Healy, following his recent injury on foot, are also in the tour 25.