A new study confirms that vitamin D supplement is less effective in the presence of obesity, and it reveals a biological mechanism to explain this observation. The study has appeared in Journal of Oil and Mineral Research.
Normal Vitamin D levels are essential for optimal health and at the same time vitamin D deficiency is a public health problem worldwide. Vitamin D is most common due to inadequate curative synthesis of cholecalciferol and / or inadequate amount of vitamin D, but can also arise as a result of pathological statements such as obesity.
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Serum concentrations of 25 (OH) D (calcidiol) are low in obesity, and fail to increase appropriately after adding to vitamin D.
The study reveals that the enzyme in the liver that contains vitamin D is a 25-hydroxyvitamin D (calcidiol), which is the main form of vitamin D in the blood. Therefore, it may be more effective to treat vitamin D inadequacy in obese individuals with calcisg rather than with other vitamin D.
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"The low rotation levels of 25-hydroxyvitamin D are common in obesity and have been attributed to the vitamin D sequence in fat cells. Here, we offer a second mechanism with more biological implications: obesity reduces the ability of liver to convert vitamin D at 25-hydroxyvitamin D, "said lead author, Dr. Jeffrey Roizen, Philadelphia Children's Hospital. "Our observations show that this nation is influencing this early stage of activate vitamin D, and suggest that the effects of liver obesity can have clinical systemic effects on bone and mineral fetabolism. we often think of low vitamin D that causes obesity, this work shows that illness or pathology (such as obesity) can cause low vitamin D. "
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