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Tübingen researchers reveal the fastest strategy of anti-resistant germs

Enter the vesting period until Wednesday, November 21, 2018, 19:00 CET / 18:00 London Time

Researchers at the University of Tübingen and the German Infection Research Center (DZIF) have successfully revealed multi-drug resistant diseases. The team led by Professor Andreas Peschel and Professor Thilo Stehle were able to explain the structure and function of an unknown protein, with the help of what pathogens such as Staphylococcus aureus asked to protect against the human immune system, such as with a clock of invisibility The study was published on Wednesday in Nature magazine.

Bacteria infections such as Staphylococcus aureus cause a number of deaths around the world. In particular fear of hospitals the stress resists the antibiotic methicillin, Staphylococcus aureus layers, or MRSA for a short period. According to a study published in early November, there were just about 670,000 anti-drug pathogens in the EU alone in 2015. 33,000 patients died.

Usually, our immune system cope well with pathogens such as bacteria or viruses. In some germs, however, the human body's defensive strategies fail, especially in incentivized patients. Unfortunately, antibiotics are ineffective against resistant pathogens. MRSAs and new antibiotics and protective vaccines are not yet seen. An accurate understanding of the protective mechanisms could allow new therapies against the bacteria.

Researchers at the University of Tübingen have now described how MRSA germs are invisible to the immune system. They were able to show that many common special MRSA germs have previously acquired anonymous protein, which means that the lithogens are no longer recognized by antibody antibodies. Tübingen scientists gave the protein the name TarP (short for Pit ribitolic acid).

"TarP changes the pattern of sugar molecules on the pathogenic surface in an unprecedented way," said Professor Andreas Peschel of the Interactive Institute for Microbiology and Infection Medicine at the University of Tübingen. "This means that the immune system can not produce antibodies to the most important MRSA antigen, the antibody". The immune system is not only "blind". It also loses the most important weapon against the pathogen.

Redesigned by phages
Tübingen researchers assume that the bacterial clutter of invisibility is the result of conflict between the pathogens and their natural enemies, the so-called voices. Bacteriophage is a class of viruses that attack bacteria, use them as a feeding cell and feed on them. In the present case, page has appeared to re-program their host using the TarP protein, thus changing the surface of the bacteria.

The first authors of the work, David Gerlach and Yinglan Guo, succeeded in explaining the mechanism and structure of TarP. "We now understand in detail how the protein works at molecular level as an enzyme," said Gerlach. The functionality analysis of the TarP structure is an excellent basis for the development of new operating substances that block TarP and make the pathogen known to the immune system. It was particularly important for the success of this work as an interdisciplinary approach, where other scientists from Denmark, Germany, Great Britain, Italy, Holland and South Korea were involved.

"TarP's discovery was a surprise for us. It's very well explained why the immune system does not often have any chance against MRSA," said Professor Thilo Stehle of & Interactive Biochemistry Institute. "The results available now will help us to develop therapies and vaccines better against the pathogens." Peschel referred to the recently approved "Control of Infection Controls for Infection Control Cluster" in the German Center for Infection Research: "This excellent networking helps us to further promote MRSA and TarP forward further. "

High resolution photo at http://www.pressefotos.uni-tuebingen.de/2018-11-19_Staphylococcus aureus.zip
Note the source!

scientific link:
Prof. Dr. Andreas Peschel
University of Tubingen
Interactive Microbiology and Infection Medicine Foundation
Phone +49 7071 29-78855
[email protected]

Prof. Dr. Thilo Stehle
University of Tubingen
Interactive Biochemistry Institute
Phone +49 7071 29-73043
[email protected]

Publication of information:
Gerlach, Guo et al, 2018, glycosylation wal gell age Staphylococcus aureus that is resistant to methicillin to avoid immunity. Nature, DOI: 10.1038 / s41586-018-0730-x (Available only after the ban expires: Wednesday, November 21, 2018, 7:00 pm CET)

idw 2018/11

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