Wednesday , May 25 2022

Living in our brain Communities of bacteria that can affect us?


Bacteria in the brain, here to the left of a seam. Image: Rosalinda Roberts, Courtney Walker and Charlene Farmer

Neurologists want to have bacteria found among men and mice. Is there a microbiologist with a brain other than the bowel microbioma?

We now know that our body is home to many guests. Our body is a shared apartment, the number of room rooms is much higher than the number of body cells. Everywhere on or in the body live large or smaller communities of microorganisms, in the bowel, in the mouth, on the skin, in the lungs or in the vaginal path. Some of the rooms are parasites that may be dangerous to their host, but many are symbizies that support physical functions or prevent the colonization of other micro organisms.

The participation of bacteria is especially so great and personal too, for some time, one speaks alongside genome microbiole, which also includes viruses, fungi or brotozoa. Not only does the microbiole contain more cells than the human body, it also contains much more genetic information.

The most well-known and the largest are the microbiole in the bowel, where many bacterial communities live. Not only are they important for digesting or affecting the immune system, there is a direct link between the bowel and the brain, so that intestinal microbiology also influences feelings, moods or physiological decisions or neurology, including neurological diseases or mental disorders. In the opposite hand, the communication also works, so that one talks about a gut-brain axis. I've seen, for example, that mice that have been microbial in intestines of more delicious honey is more curious. Microbial and intestine people with anxiety also cause greater concern in mice. It is also believed that the wet microbioma is affecting brain development at an early stage.

So far, however, it has been assumed that the brain is relatively safe from microbial guests, so that the interaction occurs indirectly by chemical substances or signs. The brain is protected by the barrier of the blood brain, which, in addition to many substances, also prevents access to blood organisms. However, if viruses, bacteria, protozoa or parasites go to the brain through the barrier of the blood-brain, through head injuries or through the ear or sinuses, it can have unfortunate results.

In the brain, many people see, for example, the protozoa Toxoplasma gondii, also known as cat parasites, because their cats are last guests, the people are intermediate guests. Here, the parasite can cross the blood-brain barrier and form jams just like in other parts of the body. In most cases, the implantation does not have any results, but it can also lead to symptoms such as flu or toxoplasmosis, enziphalitis. In addition, as shown in mice, the parasite should also affect behavior and affect the memory (Toxoplasma, the parasite that can change behavior).

But scientists are already talking about potential microbbioma in the brain. Neurobiologists from the University of Alabama presented their preliminary research results at the annual Neuroscience Association meeting. And they were so excited that even the magazines of Science, Science and Nature had reported on it. In the presentation summary, scientists under the direction of neuroanatomin Rosalinda Roberts write that it is now assumed that the bowel microbes can influence the brain and behaviors, even if it is not yet clear how this will happen. In addition, it is alleged that bacteria can cross the blood barrier and / or enter the brain through nerves that lead to the intestine. And they reported that they found bacteria in a human brains and a mouse that had not been infected or traumatized.

First, bacteria were found in 34 cases in brain by dead bodies. Half of the dead schizophrenia, the other half was mentally mental. They had taken place in different sizes. These are bacteria with a shape of a kernel, DNA, ribosomes and abdomen. It was found in the pressure of humans and mice in the hippocampus, in the prefrontal cortex and in the nigra substantia, but also in the interellog space, especially in the blood-brain barrier, in astrocytes and glucose cells. From specific locations, scientists come to the conclusion that post-mortem contamination is not a surgery. There were no focuses of inflammation either, noting that the bacterial communities were contexts in the brain. Here are the bacteria that occur in the bowel: Firmicutes, Proteobacteria and Bacteroidetes. This could be a sign of why the brain and the bowel are closely related.

It is not clear of the abstract how the bacteria go to the brain, even if the scientists suspect that this could happen through & # 39 ; r blood. And if it was true that human brains – or some of them – were representatives of bacterial communities, then of course it would be very interesting to see how they interfere with and influence influencing neuronal processes. Of course, the findings must be confirmed through further research.
(TheFlorian Rötzer)

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