Friday , October 30 2020

Why is lack of sleep bad for the heart?



In March, a study showed that around a third of French people slept during the week, less than six hours a night. Sleep time that could jeopardize their cardiovascular health. As a result of disruption to some physiological regulators, tell the researchers today.

People who are sleeping are slightly more likely to sufferstroke a heart attack the others. Several studies have already shown that. And today, researchers of theUniversity of Colorado The US seems to have revealed the basic mechanism at the end microRNAs.

these microRNAs, contains about twenty nucleotides, one of the main ways of regulating thegene expression. And that's why scientists are particularly interested. They hope that treatments that correct the changing signatures of these microRNAs could help fight diseases like cancer.

Sleep at least seven hours a night

So researchers at the University of Colorado have measured in their patients the expression of nine microRNAs already associated with a inflammation, immune function or vascular health. As a result, people who do not have enough sleep levels of miR-125A, miR-126 and miR-146a are 40-60% lower than those who sleep & # 39 n normal.

"We don't know why seven to eight hours of sleep it seems to correspond to magic number. However, it is credible that people need at least seven hours sleeping the evening to maintain important levels regulators physiological, like these microRNAs » tChristopher DeSouza, physiology professor. Research is underway to determine whether recovery of healthy sleep patterns is sufficient to restore microRNA levels.

What to remember

  • Poor sleep is associated with cardiovascular disorders.
  • Reduced microRNA concentrations can explain why.

Sleep: good sleep protects the arteries

Good nights sleep promotes cardiovascular health. But for what reason? Researchers have noted in the mouse mechanism that would explain this phenomenon; it includes a peptide produced by the. t brain who would act on that bone marrow and blood vessels.

Article from Marie-Céline Ray Published on 17/02/2019

In France, backInsermone in three people suffer from it sleep disorder. However, different studies have found a link between sleep problems a pathologieslike thesleep apnea, y diabetes, cancer, as well as cardiovascular disorders. But what can cellular and molecular mechanism explain this link between sleep and cardiovascular health?

In this study was published nature, the researchers Harvard Medical School from Boston focused on hardening arteries, or atherosclerosis. For this they worked on genetically modified mice to developatherosclerosis. Some mice could sleep as normal, while others were disturbed by sleep.

Over time, mice who were sleeping had more arteries in their arteries: their plaquesatheroma about a third more. They also had in their blood twice as many cells known to be inflamed, some of them monocytes, compared to other mice. In addition, their hypocretin level – nerohormone produced by thehypothalamus – lower.

There are hypocretins, or orixins, in neuropeptides that get their name from contraction between the words "hypothalamus" and "secretins". y neurons The hypothalamus that produces the hypocretin has projections that can be directed to other parts of the t central nervous system. According to the The Neuroscience Society Bulletinhypocretin injection induces vomiting in the rat. Hypocretin plays a role in the sleeping and wake up.

Research opening the way to new treatments

For the authors, hematopoiesis controls sleep, that is, production blood cellsand protects against atherosclerosis in mice. The mechanism is as follows: certain bone marrow cells, precursors white blood cells, they have hypocretin receptors; in the presence of hypocretin, the mice have fewer circulatory monkeys and less atherosclerosis. In contrast, without hypocretin, mice have more bonnets and atherosclerosis.

The researchers also proved the effect of hypocretin supplementation in mice. As a result, hypocretin allows mice sleeping poorly to produce less inflammatory cells and develop smaller lesions compared to non-supported mice.

These findings suggest that a poor fall comes with a reduction in the level of hypocretin that promotes inflammation and atherosclerosis. But he will do further work to find out if this connection exists in humans too and if hypocretin can be used as a t therapy.

In a statementFilip Swirski, one of the authors of the study, explains: "We have identified a mechanism for a hormone The brain controls the production of inflammatory cells in the bone marrow to protect the blood vessels from harm. " But for this beneficial effect to happen, good sleep is essential: t "This mechanism anti-inflammatory is regulated by sleep and falls when you are often disturbed by sleep or have poor sleep quality. "

Take nap to prevent high blood pressure!

Article by Claire Peltier published on 14 December 2010

For National Hypertension Day, take time to look at your sleep. In fact, high blood pressure could be linked to rest too short or not very qualitative.

  • Check out our complete file on blood pressure and high blood pressure

Hypertendus, are you sleeping well? This is the question asked by the. T French Committee against Arterial Hypertension (CFLHTA) t on the occasion of National Anti-Hypertension Day.

It is also a title bookIt is intended that everyone should realize that sleep helps to regulate the sleep blood pressure. In fact, the how often heart and weight falls during rest periods. Studies have shown that there is a shortfall sleeping (less than 7 hours a day) or poor sleep quality (snoring, sleep apnea…) often associated with high blood pressure.

Restore your cardiovascular system

Short naps It also seems to have a beneficial effect on the cardiovascular system, but, unlike them naps, it would not be possible to sleep with the night.

To be interested in sleeping yourself to improve it, it could help to keep someone's heart. So don't hesitate: talk to your doctor.

You can also browse our questions about our answershigh blood pressure.

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