Friday , February 26 2021

Is allergy come from useful mechanisms to survive?



Mum cells are immune cells found in the nose or lungs that play an important role in allergies. In the presence of an allergen, these cells secrete histamine, a chemical mediator that, once it goes into the bloodstream, will stimulate many more or less uncomfortable reactions – not eyes, tywian, vaccine flows into anaffylactic shock in the most serious cases. As their name suggests, there are some anti-allergic drugs – antihistamines – there to stop the harmful operations of mast cells.

Except, according to a study published in the Cell Metabolism and led by researchers at the University of California Irvine, led by Daniele Piomelli, it seems that these cells allow a body to survive food deprivation and / or large demand about energy related to intense physical activity.

In this case, this work shows that the histamine released by the mast cells in the liver, will trigger the formation of oleoylethanolamine (OEA), a lipid derivation that is already known to prevent the feeling of hunger. According to the Cell Metabolism study, oleoylethanolamine is also about ketogenesis, where our brains and muscles continue to operate for a certain period of time if fast and / or high efforts are physically. Mechanism that would have been crucial during our turn, when our ancestors did not always have a full fridge at hand to eat.

"Without mast cells, histamine or AEO, we could not survive a marathon or a day of hiking without cereal bars in our backpack"Piomelli explains. "What I really like is that these cells that should be" bad men "of allergy are the one that allows us to survive a long disorder or physical commitment.".

The team is now investigating whether diseases affecting the ability of mast cells to secrete histamine – thus triggering the production of an AEO – can also cause diseases such as steatosis. The "foie gras" are often predecessors of liver fibrosis and liver cancer.


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