Sunday , June 26 2022

Strong genetic evidence links depression to obesity


In the biggest study to date, it has been found that the causes behind the high correlation between obesity and depression can be genetics and not necessarily change in metabolism.

Genetic connection with higher BMI was found to be associated with higher risks of depression, with more risk to women.Pixabay

Depression and obesity are not usually confidential. In fact, several investigations have already confirmed that patients with the second, usually suffer from the first one.

What is uninstalling is what appears first: is depression due to practices that lead to excessive weight? Or does too much pressure stimulate emotional and metabolic responses that can lead to depression? Are the genes that make someone more likely to have obesity associated with those who make them more likely to depress?

A recent investigation, the most comprehensive one made in this regard, seems to solve the question. According to the study conducted by researchers at the University of Exeter (England) and the Cancer Research Center of the University of South Australia, he found the preliminary results that The High Body Mass Index (BMI) is a high risk indicator of depression depression.

"A higher BMI, with the consequences of its adverse metabolic effect, is likely to have a causal role in determining the likelihood that an individual will develop depression," read the research findings published in the Journal Journal of Epidemiology.

To reach this conclusion, the group of 19 researchers analyzed the data available in UK Biobank, a genetic information bank that collects data from around 500,000 people aged 37 to 73.

After making scratch information first, the researchers found that the BMI of 340,786 people were available on stage. This large group was inspected to determine whether they had depression or not. So, that was found There were 48,791 participants suffering from depression. The remainder came -291,995 people- in the management group.

The researchers were analyzed 73 genetic variations is associated with high BMI and have a high risk of heart disease, and look at 14 other variations that need to be made with a higher percentage of body fat, but do not increase the risk of disease and heart.

This double analysis had the objective of discriminating physiological causes of depression, with only the psychological appearance of it. "Although the first group could be linked to depression through biological or psychological mechanisms, it would only be expected that the second had a psychological effect," the researchers explained to The Guardian.

This is how the birth of a higher BMI was found to be associated with more risks of depression, with more danger to women.

In fact, that was found for every 4.7 point increase in BMI, the conflicts of depression increased by 18% in general, and by 23% among women.

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