Friday , December 4 2020

Films for the first time how our immune system kills bacteria by piercing the cells



Scientists from University College London (UK) have managed to collect for the first time one of the incredible protection mechanisms available to the human body to protect itself from invasive organisms.

"To kill bacteria in the blood, our immune system uses nanomachines we can open deadly holes in your goals. UCL scientists have now filmed these nanomachines in action, "said a statement on the university's website.

Membrane Attack Complex (MAC, for its acronym in English) t Our set of proteins are being implemented to destroy bacteria, and now you can see how we make a number of holes in the membranes of invasive cells.

In research in 2016, British researchers studied the MAC attack on a bacterial membrane and noticed that the membrane had numerous pores after the conflict protection mechanism. These holes are very small: their diameter is only 10 nanometers.

In the new study framework, they created a bacterial surface model of the lipids of E. coli. Then they released the MAC proteins and filmed the whole process using fast atomic force microscopy, a type of very high resolution microscopy that allows nanoscale images to be obtained.

We need 18 copies of the same protein to complete the hole. But after installing the first, the process stops short, forming a kind of “bottleneck”, before the rest of the proteins accumulate.

"These seem to be." [ensamblajes de proteínas] they will wait a second, allowing their potential victim to intervene in case it is one of the body's cells rather than an invasive defect, before presenting the death"The nanotechnologist Edward Parsons said. t

These holes weaken the bacteria, causing the cells to be broken and their death without damaging healthy cells. The perception may affect immunotherapy to fight cancer cells.


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