"It's our time and the first study that shows that behavior change can reduce the risk of RA seropositive." Generation is not about genes and luck, but there is an environmental component that can be adapted to start this disease. and the possibility that some people will reduce their risk or even prevent RA, "explains the author, Jeffrey Sparks, of the Rheumatology, Immunology and Allergy Division in Brigham.
To conduct their study, published in Arthritis Care & Research, Sparks and colleagues used data from the Nurses Health Study, established in 1976, and a Second Nursing Health Study, a second cohort established in 1989. And # 39; The two groups They include registered nurses from across the United States who completed bi-annual health surveys with questions that included smoking information and health status.
Among the more than 230,000 participants in this analysis, the 1,528 researchers that RA developed. The research team had a special interest in the 969 "seropositive" cases rather than "seronegative". Patients have RA seropositive autoantibodies associated with RA, and generally have more severe prominence of the disease, such as joint disorders and disability.
For positive HIV-positive, the risk began to fall around five years after women stopped smoking and continued to fall for longer than they were still smoking. Participants who are most likely to reduce their risk of AR seropositive in detail at 37 percent after 30 years. The team did not find any connection between RA seronegative and smoking, which adds further evidence to the theory that it can be RA seronegative and seropositive two complexes with different risk factors.
"One of these lessons is that you need to stop smoking in a continuous way to get the full benefit," explains Sparks, "while other diseases, such as cardiovascular disease, can give a # 39 , the best to give immediate effect, here We will see later decades of benefits to those who give up the quest. "
Although the biological mechanisms that do not connect smoking and the UK development are unclear, Sparks and colleagues believe that smoking can impact on a clinical illness process that leads to the formation of syntactic autoantibodies, Related to the UK and increasing inflammation. . As well as studying further UK biology, they want to expand their research into the involvement of men and trial trials among active smokers to see if projected prevention of RA-related autoantibodies and the sequence of the disease can be prevented. Illness among people with greater risk.
With information from Europa Press