A team of researchers from China made a major increase in the fight against Alzheimer's, having discovered a relationship between the operation of the brain path and the correct metabolism of sugar in the brain.
The study, led by doctors Nibaldo Inestrosa to Pedro Cisternas, The Center for Aging and Regeneration and the Catholic University (CARE Chile UC), has found an animal-developed method, which has successfully improved cognitive abilities in mice.
According to Cisternas, in the information reported by the EFE Agency, research carried out on animals "states that Wnt path activation stimulates glucose metabolism, mainly in neurons, A very important process in the brain, an organ that requires a lot of glucose and energy for its proper operation, especially in regions that are related to memory and memory processes, such as the cortex and hippocampus. "
The brain, he says, represents 2% of body weight, but it requires around 20% oxygen and 25% of ATP (basic nucleotide in energy and cell) from & # 39; the human body.
The ATP, Cristernas emphasizes, in the energy molecule used by cells for their essential functions and in this context, a significant aspect is that glucose metabolism is reduced in almost all neurosurgery such as Alzheimer's & # 39; s, Parkinson's and Hungtinton, "who have been in contact with a reduction in the ability of the brain to use glucose."
For his part, Dr. explained Nibaldo Inestrosa, the National Science Award, that Alzheimer's pneumonia suffer from deterioration due to the accumulation of an insoluble protein type of the beta amyloid, which interferes with the function of signaling communication and neurons with each other.
Therefore, by restoring the Wnt route, it is possible to recover the relationship between brain cells and prevent injury.
Based on that background, Researchers develop different strategies to implement the Wnt signaling path, in order to promote an improvement at an early stage or Alzheimer's disease sequence.
"We want to elaborate therapies of molecules that produce the operation of this path and therefore, the benefits of a project for Alzheimer's patients who, in the main, allow to delay memory loss. This could have a great impact to those affected and their family environment, "said Dr. Cisternas.
This finding seeks to improve the quality of life of Alzheimer's people.