Saturday , November 28 2020

New metabolic mechanism in bacteria – Medical news



An international study, led by Spanish researchers, has found a new metabolic mechanism in bacteria

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Detail of the three-dimensional structure of the protein on atomic solution / IRNASA

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Detail of the three-dimensional structure of the protein on atomic solution / IRNASA

Here is the first evidence that some of these microorganisms, living in non-mild and oxygen environments, use metabolic mechanisms that were believed to be unique to organisms that perform photosynthesis. The perception can help fight bacteria to antibiotics.

International research led by the Institute of Natural Resources and Agrobiology Salamanca (IRNASA, CSIC center) describes a new metabolic mechanism in bacteria. The perception, published in the prestigious scientific magazine Transactions of the National Sciences Academy of the United States of America (ThePNAS) is the first evidence that some bacteria that live in non-mild and oxygen environments can use metabolic mechanisms that have been considered unique to organisms that perform photosynthesis. In the biomedical field, this discovery opens a new way to fight against antibiotics to antibiotics.

Living beings produce the energy they need from food, through a very complex network of biochemical reactions, as a whole, we call metabolism. The metabolic processes that occur inside the cells underpin a molecular scale life, which the necessary energy can be obtained, for example, moving, growing or reproducing, among Many other types of essential activities.

Also, the type of metabolic reactions that occur within organism cells determine which types of substances will be nutritious for that organism and which will be toxic. For example, some bacteria use hydrogen sulphide as nutrition, but the gas is toxic to the vast majority of animals. Similarly, the special metabolism that plants possess it allows them to live only of water and sunlight, which is impossible for animals.

This discovery opens a new way to fight resist some bacteria to antibiotics

Therefore, there are many variants of metabolic reactions that occur in living beings. Given its relevance, the vast majority of the metabolic processes have been studied and have been marked in the last decades. However, it is possible to find new types of metabolic processes in specific organisms.

Unique protection of anaerobic bacteria

Now, this study led by Mónica Balsera, an IRNASA researcher, has studied a new protein that exists, in total, in some anaerobic bacteria, that is, bacteria that live in environments that have an oxygen deficiency .

This protein is a chimera of two different proteins, which usually appear in separate metabolic pathways: on the one hand, Thioredoxin Reductase (NTR) that is dependent on NADPH, which is present in each organism living that is known; and on the other hand, the Tredoredoxin Reductase depends on Ferredoxin (FTR), which excludes photosynthetic organisms.

The protein that is derived from the name Flavin-Thiorredoxin Reductase, which depends on Ferredoxin (FFTR) is special because it contains an unprecedented mixture of the function of both initial proteins . On the one hand, it interacts with ferredoxin as the FTR does and, on the other hand, uses the same binding module to a flavine memory as the NTR.

Here is the first evidence that some bacteria use metabolic mechanisms of opinion that are unique to photosynthetic organisms

As a result of this mix, a new protein is produced with unique properties described in detail, and for the first time, at work published in PNAS. To achieve this study, it was essential to have the three-dimensional structure of the protein on atomic solution, carried out by high-energy X-ray separation experiments, produced in the screenshots of ALBA (Barcelona) and Diamond ( Oxford, United Kingdom).

From a scientific point of view, the discovery is of huge interest, given that this is the first evidence that some bacteria, which live in non-oxygen-free environments, use Metabolic mechanisms that were so far were thought that were unique to photosynthetic organisms, such as algae and plants.

From the point of view of the biomedical, the study is even more relevant if possible, as some of the bacteria that this protein is found are extremely dangerous pathogen, among those who have & # 39; u include Clostridium difficult, The Clostridium botulinum a Clostridium tetani, causing pseudomembranous disease, botulism and tetanus disease, respectively.

This perception, therefore, opens the door to the development of new approaches when searching for molecules with antibiotic activity, one of the most important public health problems at present, given the fact that resistant and resistant bacteria seemingly increasing, has accelerated in recent years. years due to the use of antibiotics.


Bibliographic reference

Flavoenzyme associated with Ferrodoxin O? I Family Pyridine Nucleotide-Independent Thioredoxin Reductases. Rubén M Buey, David Fernández-Justel, José M de Pereda, José L Revuelta, Peter Schürmann, Bob B Buchanan and Mónica Balsera. Transactions of the United States National Academy of Sciences, 2018. https://doi.org/10.1073/pnas.1812781115


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