Thursday , August 18 2022

Italy Sammy Basso: a young biologist who suffers from progeria or rapid aging and has helped to find Video therapy | Genetics CRISPR | World


"The ill health of the elderly children" Sammy Basso when he was barely two years old. This rare disease suffers from a hundred people around the world, and within this deadly exemption, the young biologist is unique, as he only only survived to the age of 23, as most victims are progeria They reach the age of 13 as typical octogenous diseases turn off their lives.

It is still alive despite the serious problems of cardiovascular, respiratory and joint damage. He rarely has a hair, but despite the weakness, he decided to deceive his fate, because thanks to the work as researcher of the young biologist who finally discovered the scientists therapy genes therapy to correct the disease whose case has to hide in the genes.

Despite his illness, disorders and youth made him decide to study Physics, until he met the scientist Carlos López-Otín from the University of Oviedo, an international reference in progeria research. He was the one who convinced him to decide to study Molecular Biology and he ended up receiving in his laboratory as a student.

Thanks to López-Otín's support today Sammy Basso It is signed in the journal "Nature Medicine" one of the studies that can change its designation and other people like it.

The Inquiry into University of Oviedo next to another Salk Foundation, with Carlos López-Otín to Juan Carlos Izpisua at the head offering the test that this fast aging can be stopped. The grand magazine collects details of these independent studies where therapy with genetic editing is proven.

The study indicates that this milestone can be achieved thanks to CRISPR (read the crisper), the "Army Army Swiss" knife or a molecular scissor that allows you to transport, cut and even delete genes into will. The objective was clear: correct with the genetic editing of the gene that is responsible for this disease, which causes A collection of toxic protein in the cell nucleuss. This is the first time to treatment with permanent effects to be achieved.

However, this scientific victory does not stop there, as this is the first time that genetic ability can be shown to correct systemic disease, which affects all the cells of the organism.

Eight years of life

Scientists succeeded in achieving these results by studying mice that was produced to suffer the same Sammy Basso disease. The animals treated lived 25 per cent more. It is always difficult to translate this figure into human age, although "the current technology is likely to mean a further 7 or 8 years of life", Juan Carlos Izpisua to the Spanish medium ABC of a laboratory at the Salk Foundation.

For those born with an average life expectancy of more than 83 years, the figure may appear small. From a point of view progeria Adding an extra eight years of life to someone who does not survive beyond blueprint, however, is a great achievement. "It can help patients survive longer," says Izpisua.

Key to understanding human aging mechanism

The technique for treatment was developed progeria, although these new investigations offer numerous clues to better understand the mechanisms associated with the natural aging of the human. It will not be difficult because many Progeria symptoms are similar to those who are naturally aging.

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