Tuesday , January 19 2021

LSD allows more information to flood to the brain by changing activity in the talamws



New neurological research provides evidence that the LSD psychic drug changes the capacity of the disorders to control the flow of sensory information into other areas of the brain.

The tatws are a small part of the middle in which most sensory inputs of body flows. The new perceptions that appear in them National Science Academy Transactions, indicates that LSD reduces the filtering of information in the abuses – allowing more information or normal flooding to the brain.

"LSD and other psychedelics stimulate unique effects on perception and emotion. These effects may be interesting to understand some symptoms in psychiatric patients (for example schizophrenia), but they can also be clinically beneficial to treat other diseases (for example depression), "says study writer Katrin Preller of the University of Zurich.

"So understand how LSD operates in the brain provides information on how our brain works generally and could also have implications for the treatment of psychiatric disorders."

Based on fMRI data of 25 people, aged 20-34, researchers found that LSD changed the connectivity between the regions and the brain associated with a cortico-striato-thalamo-cortical link ( CSTC). In particular, there has been an increase in connectivity between the thalamus and several regions in the cortex.

"We tried a model that aims to explain how psychedelics work in the brain based on animal studies that have been around for around 20 years. It has been shown that this model is really true in people: & # 39 ; The relay, which usually filters information, sends more information to some areas in the cortex, "said Preller at PsyPost.

"This can explain why psychedelics stimulate the overwhelming feelings that participants tell them. It also indicates the importance of the links between the alasus and some cortical areas in psychiatric symptoms."

The researchers also found evidence that this was related to serotonergic activity. The antagonist ketanserin serotonin 2A – a drug that blocks serotonin receptors in the brain – prevents the effects of changing LSD thinking.

But the study – like every research – includes some restrictions.

"At the moment, the approach we used allowed us to experience links between a limited number of brain areas. Testing different brain areas will give a fuller picture in the future," says Preller.

The study, "Katrin H. Preller, Adeel Razi, Peter Zeidman, Philip Stämpfli, Karl J. Friston, and Franz X. Vollenweider, author," Effective connectivity changes in LSD-inspired awareness statements in humans ".


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