Scientists have hidden light on a biological process that helps to produce healthy cells, which could help to understand neurological diseases and other conditions.
Researchers investigated a housekeeping mechanism that eliminates defective proteins as they form. This process, which is common for many living things, eliminates damaged proteins, preventing their collection in cells, tissues and organs.
A better understanding of how defects can occur in protein production can help explain other diseases, including some types of anemia and abolish growth.
Scientists from the University of Edinburgh used the organism to use a simple model to look at how proteins are produced. During this process, genetic information enclosed in the DNA is copied first in an associated molecule of the RNA name and then used to produce proteins.
The team focused on part of this mechanism that eliminates partially removed proteins by forming them. This clears the way to produce further proteins.
Scientists studied burum powder called Hel2, using UV light to identify where this protein touches molecules associated with the production of protein. These interactions help Hel2 to identify defects when formulating protein.
When researchers removed Hel2 parts in direct contact, this prevented the destruction of defective proteins, showing that these links were important for the mechanism.
Partially-formed proteins can not only be obsolete but can be toxic, for example when they form protein clusters that are similar to those associated with Alzheimer's & # 39; s or Parkinson's. The study, published in Nature Communication, supported by the Institute of Molecular Biology of Europe and Wellcome.
Dr Marie-Luise Winz, from the University of Edinburgh's School of Biological Sciences, who led to the study said: "The process of removing interesting proteins during production is detected by nature, so we know it is of fundamental importance to life. More information on how this might happen could help increase the understanding of many diseases. "
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Marie-Luise Winz et al, Molecular Interactions between Hel2 and RNA that support quality control associated with ribosome, Nature Communication (2019). DOI: 10.1038 / s41467-019-08382-z