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A nut allergy pack shows medium results in a trial



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gan E.j. Mundell, Reporter Thursday

A nut allergy pack shows medium results in a trial

Introducing "exposure therapy" by a circle to help prevent the congestion of small-scale children's allergies in children is very effective, but not as good as the introduction of small amounts of food by mouth, showing new research.

The international test consisted of 356 children, aged 4 to 11, from five countries. All had been diagnosed with peanut allergy and were asked to wear either a skin belt with a very small amount of nuts (250 micrograms) or placebo area with no allergen.

I later experimented with a "nutshell," where a child is gradually fed into an increasing portion (but still small) of nuts, from 1 milligram to 300 milligrams .

The result: About a third of the children who had been wearing the patch (35.3 per cent) appeared to have been beneficial, with less response to the peanut challenge. That was true of 13.6 per cent of children who had weed the placebo zone, according to a team led by Dr. David Fleischer of the Colorado Children's Hospital in Aurora.

Still, that does that the peanut allergy park does not Help two thirds of the children who used it.

And for ethical reasons, children with severe peripheral allergies who have had a life threatening reaction – who could benefit most on treatment – were not included in the new trial.

An allergy that was not part of the study believes that more therapist may need to be thrown out.

"This study confirms that the nutshell is effective in treating badger allergy effectively, but the response rate is not as robust as expected previously," said Dr. Punished Ponda She is the main assistant of the allergy and immunology department at Northwell Health in Great Neck, N.Y.

Ponda said it was generally known that the introduction of mouth "exposure therapy" was better than methods such as carthion, but risks of sudden anaphylactic reactions can arise with oral administration. So, it is still hopeful that nappy therapy can become an option.

"It is anticipated that this treatment will have a place to handle a food allergy in the future," said Ponda, "but it will have to explain the details of dosage and expected response rates."

The study was funded by the DBV Technologies biopharmaceutical company and published on February 22 Open the JAMA Network.

In an editorial that accompanies the study, said the deputy magazine editor, Dr. Jody Zylke, said "these theoretical advantages [patch] This method contains easy to use and lower risk of allergic reactions. "

In fact, he noted that patch tolerance was very high – 98.5 per cent of patients used the treatment as directed.

But Zylke added that the results of the new trial "are not easy to interpret." Whatever statistics-based arguments about the significance of the new findings, doctors will have to determine with patients whether a 35.3 percent response with the peanut package is worthwhile, "he said.


An experimental peanut allergy pack promises


More information:
Punita Ponda, M.D., principal assistant, allergy and immunology department, Northwell Health, Great Neck, N.Y .; Open the JAMA Network, February 22, 2019

The American College of Allergy, Asthma and Immunology offers more peanut allergy.

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Enwi:
Nut allergy pack shows medium results in the trial (2019, February 22)
which was restored on 22 February 2019
o https://medicalxpress.com/news/2019-02-peanut-allergy-patch-middling-results.html

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