Monday , January 17 2022

Why obesity changes the function of adipocytes – Digital NOD


Obesity is a disease that has become an important public health problem, as well as a risk factor in diseases such as type 2 diabetes, cardiovascular diseases and some types of cancer.

This study carried out among people has shown the importance of changing epigenic marks due to obesity. (Photo: Pixabay)

Although it is traditionally considered due to an imbalance between drinking and energy spending that favored the storage of fat, it is now recognized that the interaction between environmental and genetic factors (what is called epigenetics) plays a key role in its development.

Researchers at the Center for Biomedical Research in the Diabetes and Associated Metabolic Diseases (Ciberdem) Network, from the group led by Joan Vendrell and Sonia Fernández-Veledo at the newly created Pere Virgili Sanitary Research Institute (IISPV) (Catalunya, Spain) Give one other step in the information about the processes that triggered these genes-environment interaction.

Experts have identified a new mechanism where obesity leaves an epigenic edition on adipocyte precursor cells that determine the shortcomings of the new fat cells produced.

Previous group / or group studies have already revealed that adipocyte precursor cells in obese patients are not working correctly. However, to date the molecular basis of these modifications was not known.

"Subcutaneous adipose tissue of obesity subjects includes a proactive set of adipocyte precursor cell cells and there is evidence of obesity and loss of cell cell function", explains Sonia Fernández Veledo, the final signatory of the study ; It ended up being published in the Journal of Obesity Journal.

An adequate active population of adipocyte predecessors is essential in extending the accuracy of adipose tissues, lipid control and lipotoxicity prevention in the face of a chronic positive energy balance (that is, when all calories that are hanged are not & # 39 ; burn & # 39;). .

"We believe that a better understanding of the biology of this set of precursor cell cells could contribute to the development of new strategies designed to tackle obesity or promote the expansion of healthy glue tissue", adds to the specialist.

To do this, this new work was studied cell cells derived from adipose tissue (predecessors) and mature adipocytes of healthy patients being thin and obese.

"Our work shows that obesity stimulates important epigenic changes in the DNA of the predecessor cells, which determine the shortcomings of the new adipocytes produced," said Joan Vendrell, Ciberdem group leader at the IISPV.

"Obesity is the conditions of adipocyte precursor cell cells with a dynamic loss of DNA methylation in selective regions that can cause white tissue discipline and eventually develop metabolic syndromes in obesity," he said.

One of the most suitable genes is the transcript factor TBX15, a factor associated with adipogenesis, fat distribution and browning & # 39; (conversion of white fat in brown fat, the latter is healthy and necessary for the body).

The study showed that TBX15 is one of the genes with the greatest changes at epigenic level in the predecessor cells of the obese, which means it is overexpressed in these cells . "TBX15 shows a strong loss of epigenic marks with a corresponding increase in gene expression and protein expression," they explain.

The work has identified that TBX15 is a mitochondrial mass regulator in obese adipocytes, a basic organelle in the metabolic regulation of cells responsible for cell intake. "The increase of TBX15 in the adipose tissue of obese patients causes a change to the mitochondrial network, producing changes in shape and number," added the researchers.

This new research carried out among people has shown the importance of changing epigenic marks due to obesity in the future function of adipocytes, supporting the theory of precursor's proactive activity as a key event in this disease.

"Currently, we are studying if this epigenic footprint is reversible, that is, if the weight loss of the epigenic changes caused by obesity can be reversed," said Joan Vendrell.

Source: Cyber

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