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The parents' biological clock runs faster than before – 02/12/2018



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The biological clock also runs for fathers. And the latest research suggests that it does so faster than before.

If considered so farHe was 55 years old When the father's age was able to have some cases on the baby's health due to the accumulation of more chromosome changes in the sperm, a new study of Stanford University's School of Medicine that has reviewed more than 40 million births suggests the risks start 35 years and are significant of 45.

For over 45s, they find 14% more premature babies

In particular, Stanford scientists claim that The age of this older father is a risk for the baby to have problems at birthFrom low pressure to stimuli, through the need for respiratory breathing or admission to the neonatal intensive care unit (NICU).

Data & study – published in the British Medical Journal – suggests that once variables such as mother's age, race, education, educational level, marital status or smoking history have been managed, Once the father is over the age of 35, there is a slight increase in the risks at birth because with each year that he is a man of his age, he accumulates two new surges on the DNA of sperm.

Once the father is over the age of 35, there is a slight increase in the risks at birth because, with each year of the age of a man, he accumulates two new average dizziness of sperm.

Once the father is over the age of 35, there is a slight increase in the risks at birth because, with each year of the age of a man, he accumulates two new average dizziness of sperm.

Therefore, Babies born to men aged 45 or over were 14% more likely to be born prematurely, from introducing low pressure and admitted to the NICU; those with parents aged between 25 and 34 (average paternity age in the United States). Y the risk of seizure increases, according to data & report, 18%. Y After 50 years, the likelihood of need for ventilation at birth was 10% higher, and that help in the ICU had increased by 28%.

In particular, Stanford scientists say that the elder is the father, the more the risk that the baby will have problems at birth: from low pressure to stimuli, by e Need for respiratory aided or admitted to the neonatal intensive care care unit (NICU).

These collections are not surprised by Rafael Oliva, a specialist in epigenetics and spermatozoa epigenome and the head of the research group in the molecular molecular reproduction of Idibaps, a teacher in the UB and a consultant at the Clinical Clinical Diagnostic Center. "It's interesting work and coincides with what other investigations show: the role of the father in the stomach and in the son's health is more important than what we thought and that the men's biological clock, "he said.

The oldest is the father, the more the risk that the baby will have problems at birth, says a new study.

The oldest is the father, the more the risk that the baby will have problems at birth, says a new study.

Also, Julio Herrero, the head of reproduction of Vall's Hebron, believes that this study is relevant because highlights the factor of age of the male parent – which is not normally considered because he was believed to have little influence and after 55 years. However, it is considered that a warning should be taken by the definite results of the investigation because it is retrospective study, to do the forms that the doctors or </ o> are; The parents have completed those 40 million births, which group the mums, are age range too wide to assess whether the risks to a birth are attributable to The age of the father also influences those who are derived from the couple's age or that is the first child to that woman. "The important thing is that it highlights the need to study the causes of the father's age and the male biological clock with more depth, but it has to be done projectively and take the couples of an older parent's control group with young mothers, "said Herrero.

Alvaro Vives, an Andrologist responsible for the Male Dexeus Unit, agrees that it is difficult to study on such a high degree of not having a specific prejudice, although it admits that there are more changes at the level Chromosomics are men and can cause fetal problems. "In fact, in public health in Catalan, access to in vitro fertilization is limited if the woman is older than 38 or the 55 year old man," he said. Vives believes that the fact that many fertility centers run by gynecologists give more focus on women's conditionsr, "but 50% fertility is a man's responsibility, and there are many factors and habits – eating toxins, eating coffee, tea, overweight, tobacco … – which influences" the quality of the sperm and in fertility, in changes affecting the development of pregnancy and can cause premature babies or with respiratory problems, which is what Stanford's study indicates.

"It's interesting work and it fits with what other research shows: the role of the father in pregnancy and child health is more important than we thought and The men's biological clock also "

Rafael Oliva, an expert in epigenetics and sperm epigenics

At a European Society of Reproduction and Embryology in 2017, a study by biologist from Harvard University who came to the conclusion was presented, following the analysis of 19,000 in vitro fertilization treatments, When young women tried to have children with men over 40 years of age, pregnancy was more likely to fail. On the other hand, the results were better when the man had not reached his tenths.

The oldest is the father, the more the risk that the baby will have problems at birth, says a new study.

The oldest is the father, the more the risk that the baby will have problems at birth, says a new study.

From the epigenetics field, Oliva explains that, although there is still a lot of information in people about everything sperm-transmitted, in the last two years there has been accumulation of evidence in animals that is a way of live men among them who even eat the experiences they live – causes measurable changes in your sperm and are transferred to next generation and sometimes even to the third. "It's used to concentrate the concern about mothers because the oocy was very much compared to the sperm and for a long time it was thought that if in the infants there was more legacy than & The only DNA is a mother, through the cytoplasmic factors of the oocyte, because it was believed that sperm did not contain DNA alone, but today it is very clear that the father's son is organized by histones and prototamines, which with the potential to provide epigenetic information ", summarizes the Idibaps researcher in the sperm.

This week, the PNAS scientific journal reiterated that a team of doctors in the United States has also put an end to the belief that the DNA of mitochondria – the structures that give energy to cells – is transmitted by mothers only, after identifying more than a dozen people in three different families who have inherited a mitochondria from both parents. The researchers are of the opinion, however, that it is an exception to the general rule, that is when the patent mitochondria goes to the zygote that is a chemical label that # 39; n their marking destroyed. Anyway, The discovery is that the biological legacy that someone receives goes beyond genetic sequences and is marked by the impression that life, customs and environment have left on both parents.

Source: La Vanguardia

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