Sunday , August 7 2022

Salt affects immune responses to allergies – Science



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A team of researchers have found that salt affects immune responses to allergic diseases.

The research led by Christina Zielinski, from the Munich Technical University (Germany), has shown in cell cultures that salt leads to the formation of Th2 cells, which are immune and are sent in allergic conditions such as atopic dermatitis .

T cells play an important part in immune conditions of this type, as they are an essential aspect of the body's resistance to infections. If they are not controlled, they can also develop pathological responses and start attacking parts of their body or adverse substances such as allergens.

When such functions occur, Th2 cells, a subset of T cells, can cause inflammatory skin conditions such as atopic dermatitis.

This implies a higher production of the interleukin 4 (IL-4) and interleukin 13 (IL-13) proteins, although it is still unknown what's triggering and this deficit . The team also found that the skin of patients with atopic dermatitis with common skin disorders contained high levels of sodium chloride, stating that it could play an important part in the development of that disease and other allergic disorders.

"The highest sodium levels in the affected skin fit perfectly with another feature of atopic dermatitis: Staphylococcus aureus bacteria," said Zielinski.

This type of bacteria, according to the researcher, is growing in salted conditions, unlike other bacteria, which are actually damaged by salt.

Scientists suspect that this increase due to non-genetic factors, such as the use of too much sodium chloride in the diet of foods has been processed, but, according to the authors, "& # 39 ; n yet again how these cause contributing to the immune abnormalities observed in allergic and automatic diseases ".

In addition, biopsies of adult disease skin suffering from atopic dermatitis were digesting higher concentrations of sodium chloride, compared to a skin that did not suffer from disease in the same patients and in others with psoriasis.

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