Friday , August 19 2022

Hantavirus: a sequence in the complete genome of the epuyén stress



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Researchers used An Carlos Dr. Malbrán uses first generation sequence technology Credit: Hernán Zenteno

Here is the first time to know all the genetic features of the South Andes; this confirms its ability to transfer from person to person

The variation of the De Andes from the haunt virus caused by the case is still active, from

Epuyén

and the environment in

Chubut

, not only can it be transmitted from person to person, but it is similar to the one that is caused 23 years ago, only 40 kilometers away, in the town of Río Negro El Bolsón.

Since then, this stress was modified to survive and did so by genetic changes that reinforced its ability to spread, according to the results of the first analysis of the complete genome of the known Andes of the world. He was responsible for the Valeria Martínez team, the National Institute of Infectious Diseases Molecular Biology Service, the national reference laboratory for

hantavirus

.

The likelihood of the virus found in the samples of 34 people infected since last November was 99.9%. This confirms that the transmission mechanism is
This case was from person to person. At the same time, compared to other haint virus infections was endemic in the country, it was just as close to the stress of the cases in 1996.

When the first studies on El Bolsón's cases were published by the common variation to the southern region of Argentina and Chile, so their name, and described their ability to transfer inter-human, experts of the National Ministry of Laboratories and Health Organizations (Anlis) Dr. Carlos Malbrán gets information on some pieces of viral DNA.

Now, with new generation sequencing technologies and samples analyzed by all the people who were sick and died in this case, the Martinez-led team was able to disclose complete information of the genetic material of the endemic Patagonia strain that caused a pulmonary syndrome from Hantavirus (SPH) in Epuyén, Trevelín, El Maitén, in Chubut, as well as El Bolsón and Palena, in Chile.

With this data, which is derived from the three parts of viral genetic material, rather than small parts of two of these segments found to date, we can Later explain the differences in the immunological responses that patients or their relationship with some identified mutations, among other questions, may have studied.

"The case, of unprecedented size, contained 34 cases, of which 12 died – re-used by Anlis Malbrán this week by a statement on the results obtained." The case mortality rate was almost twice as high as women as men (40 against 21.4%). The last cases started with symptoms on this 7th of this month and still have their hospitals. Towards the end of December, home insulation was placed on people who had been in contact with confirmed cases. it has been able to limit the expansion of more cases. "

The way in which people became ill ("grouped and short-term cases"), the small number of places where they lived and the information of the environmental study where epidemiologists could have infections and swonoses rely on it since the first weeks of the idea that the epidemic case was an exposure to the virus that wild beetles were eliminated through urine, feces or saliva.

"The possibility that a viral dispersion of person to person, as it was posted in front, was dispersed early," according to studies published in 1998 and 2005 on the El Bolson case, where he was Interpersonal transfer is self-limiting and prevents new infections. . In Epuyen and its surroundings, the isolation of more than one hundred people in contact with the illness, for the health authorities, restricts the transfer.

"This is one of the most widely distributed zoonotic viruses that cause two syndromes: hemorrhagic fever with kidney syndrome, high deaths and low deaths in Asia and Europe, and HPS in America, but with lower cases and higher deaths, as if, in some respect, they were compensated with these differences, "explained Martinez.
THE NATIONAL.

Claudia Perandones said, an intervention by Anlis Malbrán: "We did not have the complete sequence of the viral genome as today, now the level of evidence is bigger." With the previous information, there may be differences in some of the genomic parts. and, as we can not fully evaluate it, we do not know, today we know all the genetic information of the South Andes and this is the first time that this data is available. "

There were Perandones in Epuyen and the environment with the team of professionals who sent the Nation's Ministry of Health to Chubut
to include the case. He recalled that the national referral laboratory was developed last year, the recombinant antigen (a piece of virus introduced to a bacterium to be able to reproduce huge) for very diagnostic tests through a blood sample for a place There is a suspicion of the disease.

"Further," added Martinez, "avoids treating the virus for normal work with laboratory tests, such as the diagnosis of the infection."

With these and those known facts, in the Anlis Malbrán trust, a high risk crisis should not be repeated due to its transfer ease as Epuyén. "This is the chance to get perfect data on the South Andes and to improve the warning level, and hopefully it will help to prevent other causes," said Martinez.

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