Friday , August 19 2022

Florida scientists help disqualify the white chest genome that could have the treatment for cancer



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The wonderful white shark often appears as a great fiction of the deep blue sea, but the iconic predator may be key to some incredible health checks.

Scientist-led international team of the New Southeastern University in Davie, along with the Cornell University and the Monterey Bay Aquarium, the whole genome followed the great white shark and compared to genomes from a variety of other vertebrates, including the big whale shark and the men.

The untied genome reveals clues about how great white sharks are as good as healing and cancer resistant wounds.

An important aspect of the uninhabited genome, which is one and a half times more than a human being, is that Progression changes related to DNA repairs, DNA response and DNA tolerance were detected. It is known that the opposite phenomenon, the genom's instability, which results from accumulated damage in DNA, is precursor for men with many cancer-related diseases and age-related diseases.

The study was published online on February 18 in the magazine National Science Academy Transactions.

"Genom instability is a very important issue in many serious human diseases; Now, we discover that nature has developed intelligent strategies to maintain the stability of genomes in this great body and long life sharks "said Mahmood Shivji, Ph.D., director of the Shark Research Center Shark Research Center of the NSU and Guy Harvey Research Foundation. "There's still a lot of learning about these evolutionary wonders, including information that might be useful in addressing cancer and age-related diseases, and improving healthy healing treatments among people, as we discover how these animals make "

The white chest genome revealed not only its huge size but also a number of genetic changes that could be behind the evolutionary success of long sharks and long-lived.

It was also notable that the white shark genome contained a very high number of "jumping genes" or transformations, and in this case, a specific type, called LINEs. In fact, this is one of the highest proportions of LINE (almost 30%) found in vertebrates to date.

"It is known that these LINEs cause genome instability by creating double string cuts in the DNA, "said Michael Stanhope, Ph.D., from the Faculty of Veterinary Medicine at Cornell University.. "This range of LINE in the white chest genome may be a strong selective agent for the evolution of efficient DNA repair mechanisms, and it is reflected in the positive choice and enriching so many genes on for stomach stability. "

The discovery that the whale shark also these key modifications of genome stability were significant because, theoretically, the risk of cancer development should increase with cell numbers (large bodies) as with organism life: there is statistical support for the body's positive relationship. The extent and risk of cancer within a species. Interestingly, this does not tend to catch between species.

Contrary to expectations, large animals do not suffer from cancer more often than people, suggesting they have developed advanced cancer protection capabilities. Genetic innovations found in the genome stability genes in the white shark and the whale could be adaptations that facilitate the development of their large bodies and their long-lived life.

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