With molecular studies, the National Polytechnic Institute (IPN) proven that 100% of the Human Papilloma Virus (HPV), centered on the uterine cervix of 29 women in Mexico City, was treated with photodynamic therapy, a disadvantageous technique that can be an effective means of preventing this neoplas, which is the second cause of death among Mexican women.
# InvestigationPN They get rid of one hundred percent of human papapluvavirus. As part of World Day Against Cancer 2019, scientist Eva Ramón Gallegos shared the results that he has done for 20 years. https://t.co/XrrWvtZC44 pic.twitter.com/yHxQL8FOxo
– IPN (@IPN_MX) February 3, 2019
In the World War II framework for 2019: Creating a World without Cervical Cancer, the scientist at the National School of Biological Sciences (ENCB), Eva Ramón Gallegos, explained that photodynamic therapy as well as the elimination of HPV (a pathogenic agent of the main cause of cancer mouth of the womb), it also eliminates premalignant cervical lesions very early, as shown in this pilot study.
The researcher, who has over two decades studied the effect of photodynamic therapy on different neoplasms (melanoma, breast cancer and cervical cancer), in the clinical period 420 Oaxaca and Veracruz patients have been treated with & # 39 ; this therapy. In addition to the 29 in Mexico City, those infected with HPV had pre-aligning lesions on the cervix or had both conditions. He mentioned that the treatment was done in two stages under two different schemes of qualification and therapy.
"In the first part – where women Oaxaca and Veracruz were involved – the results were encouraging.
When applying the caption in the capitals, there was also a very hopeful effect, which opens the possibility of making more effective treatment, using the scheme that suits patients' situations, " he says.
Dr. explained Ramón Gallegos said that therapy meant the application of a drug of the aminolevilin acid acid and serpentic acid, which after four hours is transformed into protoporphyrin IX, fluorescent chemistry accruing in the cells that have & # 39; Defaults, which eliminates a special laser traw, only incorporates the structures that have been incorporated into it.
In the first part of the investigation, the procedure was applied three times with a 48 hour edge each, with radiation time per case and type of injury. Reviews have been made and diagnostic studies have been repeated.
The results were as follows: People who had the virus only had an injury, HPV was eliminated in 85 per cent; In HPV patients with lesions, he had an 85 per cent efficiency, and those who had lesions without HPV succeeded to be 42 percent.
The IPN researcher noted that women in Mexico City have doubled the concentration of aminolevilin acid delta. The procedure was performed twice with a 48 hour edge. They also conducted the reviews and diagnostic studies.
The results were as follows: HPV was eliminated in 100 per cent of patients carrying it without injury, 64.3 per cent in women with HPV and lesions, and 57.2 per cent in those with lesions without HPV.
Before applying for photodynamic therapy for patients, colposcopy, cytology (papilla smear), hybrid holding, polymerase chain reaction (PCR) and a biopsy performed to diagnose pre-signage lesions and / or HPV infection.
At the end of the procedure, the same studies were repeated and the effectiveness of the treatment that was confirmed was confirmed. He said photodynamic therapy was safe and free from side effects.
"Unlike other treatments, it's only damaged cells that have been damaged and it does not affect healthy structures, so it has great potential to reduce the death rate of cervical cancer , "he said.
The expert explained that there was also a positive impact on the plan with the application of the plan on removing pathogenic bacterial stresses.
"Percentage of women had infections caused by Chlamydia trachomatis (sexually transmitted) and / or Candida albicans, which were eliminated with treatment in 81 and 80 per cent respectively. The bacterial flora & While contributing to the health of the genital tract remains practically completely, "he said.
Dr. Eva Ramón Gallegos has achieved these developments thanks to the collaboration of Elizabeth Maldonado Alvarado to María Teresa López Cárdenas (who received the doctorate with the project), Alejandro Martínez Escobar (master's degree), Araceli Espinosa Montesinos (a specialist in Gynecology at the ISSSTE Ignacio Zaragoza Regional Hospital), Adriana Jiménez Hernández (postdoctoral stay), Martha Olivia Osorio Peralta (cyclicist of the Cancerology of Guerrero State Institute), Alejandra Moreno Vázquez (pathology specialist of the National XXI Siglo XXI Medical Center & # 39; r IMSS) to Lydia Alejandra Martínez Guzmán (Head of the Hybrid Capacity Laboratory of the Ministry of Health of Mexico City).
He also counted with the co-operation of the experts: Marco Antonio Amoroso Hernández and Ángel Laguna Cancino (Oaxaca) to Dora Estela Jovel Galdamez, Barbara Carrión Solano, Guadalupe Balderas Martínez; Eduarda Parra Rossana, Inés Castellanos Oliveros, Rosa Linda Bello Leiva, Ma. Eugenia Melo Petrone, Gumaro Narciso Morales and Petrona Jiménez Martínez (Veracruz).