Sunday , August 7 2022

Born in an Adverse Experiment on Embryos Points for New Stroke Treatment



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He investigated and criticized last year's researcher in China to eliminate gene in dual women at the embryonic stage in a HIV protection attempt. A new study suggests that using a drug to eliminate the same gene in people with stroke injuries or traumatic disorders can help to improve their recovery.

The new work shows the benefits of extinguishing the gene in mice caused by a stroke by using the drug, which has already been approved as a HIV treatment. It also focuses on a sample of people born naturally without the gene. People without the gene improve faster and more fully from a stroke or the general population, found by the researchers.

The combined results suggest that the drug could boost recovery in people after stroke or traumatic injuries to the brain, says S. Thomas Carmichael, senior research researcher and neurologist at the University of California , Los Angeles, David Geffen School of Medicine. His team has started a follow-up human study to prove the drug's effectiveness.

The combination of mouse research and increasing the genetic data of people to confirm the relevance of drug targets makes the new research a "notable paper," said Jin-Moo Lee, co-director of Barnes-Jewish Hospital and Washington University Stroke and Cherebrovascular Center in Saint Louis that was not part of the work.

At the end of 2018, He Jiankui, then at the University of South Science and Technology in China, said he had edited CCR5 genes of dual women at the embryonic step in an attempt to protect HIV infection. The first result of her type was female bees born unborn born CCR5, He said.

Carmichael and others have spent years looking for genes and other biological paths that could lead to medications to help repair their own brain after injury or stroke. CCR5 is the first candidate of such a kind to show a real promise, says some experts. For stroke patients and traumatic brain injuries, "I think this is the beginning of hope," said Alcino Silva, a neuroscience at U.C.L.A. who worked with Carmichael on the new study. The results this week were published in Cell.

The drug used to stop activity CCR5 has been on the market since 2007 and is approved as a treatment to slow down the rise of HIV and AIDS. Carmichael gave the drug, from the name marviroc, to strokes caused by strokes. Hitting the activity of the gene in the brain's motor neurons had had a huge impact on recovery, "he said. The drug can not easily cross the barrier in the blood brain but it has enough to keep brain connections associated with chemical signals and increase connectivity between regions & # 39 ; The brain, which showed the study.

For the human validation element of the study, the team examined 68 individuals without CCR5 genes, together with 446 controls. Those who suffered from a stroke-and also had the faster-recovered natural generation movement abilities and had fewer cervical months after the stroke than patients who did not completely CCR5. The exact mechanism behind the result is not known. In healthy people CCR5 it is believed that a gene promotes learning and memory by acting as a "stop" signal, telling neurons to accept only one memory and to catch it, rather than continuing to receive and keep all the signs that come to me in, says Carmichael. Immediately after having a stroke or injury to the brain, the gene helps to excite neurons, helping to limit damage, he says. But if the gene keeps pumping out of "stop" signs, it also interferes with the ability of the brain to build new connections and repair damage, he added.

Carmichael's approach is to eliminate these signals by starting people on the drug about five to seven days after a stroke and lasting for about three months, allowing the brain to have a better chance to recover. In the current clinical trial, participants also have intense physical therapy to restore movement. This two-way approach to treatment is important, says Steven Cramer, a stroke recovery specialist at the University of California, Irvine, who did not take part in the research. Drug therapy can open the door to re-integrate brain circuits, but there is also a need for recovery effort – such as learning the task in the first place – it does. "Just because you spray magic pixie dust on the brain, it does not mean that you solve the problem," he said. "You have to share it with experienced training."

Cramer says he was thinking about treatment with anti-CCR5 drugs could become "one of the main pillars" of therapeutic developments in stroke recovery.

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