Thursday , October 6 2022

Your Grandma may be old, but that does not mean you, researchers say


"We know that people who are investigating their families are very interested in the longevity issue," said Cathy Ball, co-author of the study and chief scientific officer at Ancestry, a consumer genetics company which provides an online family history resource.

Genetic differences explain only 15% to 30% of longevity, previous studies suggest, and these are the non-genetic differences between us – such as how we eat and do we have a fatal accident – It explains why one person has a life longer than another.

Scientists from Calico Life Sciences LLC, a Google-funded company, focused on aging biology, collaborating with researchers from Ancestry to investigate the genetic influence on life periods. They analyze unknown family tree structures – or "pedigrees" – which included birth year, death year, birthplace and family connections for 439,361,203 people. The family trees or these counties were produced by subscribers of Ancestry.

The large size and scope of the database allowed Calico scientists to "look across families over generations, analyze the longevity of not just members of the family, but also important among the laws," Ball wrote in an email.

With mathematical and statistical calculations, the team, for siblings and cousins, found that the longevity viability – or how much variation in people's lives were attributed to genetic variations – was the same with previously identified studies. Specifically, genes explained between 20% and 30% of longevity, with this estimate falling below 15% for family relationships of another.

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The researchers also found that the rest of the spouses were similar – more than brothers and sisters of another. Possible explanation: A spouse is living in the same home and thus shares important non-genetic factors, such as diet and general lifestyle.

Yet, the results of the study also showed that brothers and sisters and first friends-in-law live in the same way even though they are not relatives of blood and who do not share living space.

What would it count on this perception? The authors of the opinion that a "likely match" is a likely explanation.

"Mathematical mating is a corresponding pattern where individuals with similar phenotypes complement each other more often than is expected under random equivalents," wrote J. Graham Ruby, leading author of the study and scientist and chief researcher in Calico, in an email.
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Obviously, no-one knows when a potential partner or partner dies, so in this case mixed mating would be based on secondary features. For example, income is known to influence life's life, when eating healthy and caring for your health is a bit related to money. If people from families of equal income tend to marry each other, this would explain similar longevity across non-family relationships, the study suggests.

Without a corresponding choice in their calculations, researchers estimated that heritability does not explain no more than 7% of longevity, possibly even less.

Your own genes can not save you from an early death.

Genetic contributions to longevity

The new research adds to the "clues about what drives aging," said David Melzer, an epidemiologist and public health teacher at the University of Exeter Medical School in the UK and a teacher at the Age Center at the University of Connecticut Center in the United States.

Melzer, who was not part of the study, wrote in an email that "it would have been nice to see" the estimates for viability in exceptional longevity cases, because centenaries are considered to have a higher level of viability for longevity than others.

Melzer and Luke C. Pilling, a research colleague in epidemiology of genomics at the University of Exeter Medical School, have also studied long-term genetics.

"Our own recent estimate of the viability of parents' parents is directly from the common genius fluctuations present in 75,000 people in Britain at 8.47%," suggesting "totality of life "an individual between 10% and 20%, Melzer explained. This is "significantly higher" than 7% or less suggested by the new family study, he said.

He noted that more than 20 gene have been identified for longevity.

"These include genes that interact with health behavior, such as the nicotine receptor gene," says Melzer. He and his colleagues also found genes that influenced cell failure or individual cell deterioration. "It's likely that many genetic variations of this kind are about life and aging," he said.

Ultimately, Ball said, "although there is a genetic component, this study shows that many other forces have a big impact in your life."

The results suggest that anyone who wishes to make a long life would do better to eat properly and exercise, rather than relying on good genes and grandpa .

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