Monday , January 25 2021

Fish mucus offers potential new antibiotics

Researchers have identified an unused antibiotic candidate in the protective mucus that is cooking young fish t

With current antibiotics reducing in effectiveness against multi-drug pathogens, researchers have identified an antibiotic candidate that is not touched in the protective mucus cooking young fish.

The mucus contains bacteria with a promising antibiotic activity against known pathogen-even dangerous organisms, such as the microbe causing MRSA infections.

This sticky substance protects fish from bacteria, fungi, and viruses in their environment, catching the microbes before they can cause infections. The scum is also rich in polysaccharides and peptides that are known to have antibacterial activity.

"Fish mucus is very interesting because the environment in which the fish live is complex," said Molly Austin, an undergraduate chemistry student at Oregon State University.

"They are in touch with our environment through the time with a number of pathogenic viruses."

The researchers will be presented at the American Chemical Society (ACS) Spring 2019 National Meeting and Demonstration.

For the study, the mucus was swallowed by benthic fish and juvenile fish caught off the coast of Southern California. The team examined young fish because they had a less developed immune system and more mucus on the outside of their scales which could contain a higher concentration of active bacteria than adult fish.

They isolated and screened 47 different types of bacteria from the scum.

Five bacterial parts strongly suppressed methicillin resistant S. aureus (MRSA) and three prevented Candida albicans, a pathogenic fungus for humans.

Bacteria from mucus derived from a particular Pacific pink gate showed a strong activity against MRSA and against a cell line of carcinoma in the colon.

The study could also help reduce the use of antibiotics in fish farming by leading to better antibiotics that have been specifically targeted at the microbes that stick to some types of antibiotics. fish.

Although new chemical reactors have been found in human microbiology, the equivalent of the sea remains relatively unequivocal.

It would be interesting to find out if anything in the mucus, which protects the fish, could actually help protect people.


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